The antiinflammatory activity and LD50 of Ocimum forskolei Benth., family Lamiaceae | ||
| Journal of Advanced Biomedical and Pharmaceutical Sciences | ||
| Article 5, Volume 2, Issue 3, July 2019, Pages 116-120 PDF (568.47 K) | ||
| Document Type: Short Communication. | ||
| DOI: 10.21608/jabps.2019.12973.1048 | ||
| Authors | ||
| Eman Maher Zahran* 1; Hany Ezzat khalil2; Samar Yehia Desoukey3; Mostafa Ahmed Fouad3; Mohamed Salah Kamel1, 3 | ||
| 1Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, 61111 New Minia, Egypt | ||
| 2Department of Pharmaceutical Sciences, Faculty of Clinical Pharmacy, King Faisal University, 31982 Al-Ahsa, Saudi Arabia | ||
| 3Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt | ||
| Abstract | ||
| The present study aimed to determine the lethal dose {LD50} using acute toxicity models and evaluate the anti-inflammatory activity of the total ethanolic extract (TEE) and different fractions of Ocimum forskolei Benth. aerial parts (leaves and stems) following the carrageenan-induced paw edema model in rats. The results obtained revealed that the LD50 value of the TEE was 8 g/kg body weight, while the extract and different fractions showed a significant decrease in paw edema, especially the aqueous fraction treated group with a % inhibition of (40.77 %, P < 0.001) in comparison with indomethacin (55.55 %, P < 0.001) as a standard. | ||
| Keywords | ||
| Ocimum forskolei; Lamiaceae; Antiinflammatory; aqueous fraction | ||
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