The Relationship between Serum Leptin and Blood Pressure in Obese and Non Obese Male Subjects | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 5, Volume 31, Issue 2, June 2011, Pages 63-76 PDF (259.45 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2011.36094 | ||
| Authors | ||
| Hassan Eissa1; Sahar Kamal1; Tarek Ali* 2; Ahmed T2 | ||
| 1Department of physiology, Faculty of Medicine, Cairo University, Egypt | ||
| 2Department of physiology, Faculty of Medicine, Beni-Suef University, Egypt | ||
| Abstract | ||
| Objectives: To clarify the relationship between serum leptin level and arterial blood pressure (ABP) and lipid profile in obese and non-obese male subjects. Methods: The present study was performed in Beni Suef University, Faculty of medicine between December 2007 and December 2008. Fasting serum leptin level, arterial blood pressure, lipid profile, waist circumference (WC) and body mass index (BMI) were measured in 10 lean normotensive (LN), 10 obese normotensive (ON), 10 lean hypertensive (LH) and 10 obese hypertensive males (OH). Results: In the present study, serum leptin, BMI, and WC were significantly elevated in obese subjects than in lean subjects whether normotensive or hypertensive (P < 0.001). In lean groups, serum leptin level was significantly higher in hypertensive than in normotensive persons (P < 0.001). In all studied subjects, mean ABP was significantly related to serum leptin. In obese groups, and in lean groups, serum leptin was positively correlated with mean ABP and all measured lipid profile parameters except high density lipoprotein (HDL) to which it was negatively correlated. Serum leptin was positively correlated with WC in obese normotensive group, (r =0.657) ( p= 0.039 ), but it was positively correlated with BMI in obese hypertensive group (r =0.675) ( p=.032). Conclusion: This study suggested that hyperleptinemia may play a role in the pathophysiology of hypertension independently of adiposity and the most correlated parameter to mean ABP among the measured parameters was serum leptin. | ||
| Keywords | ||
| leptin; Hypertension; Obese. Lipid profile | ||
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