PROGNOSTIC VALUE OF CTBP2 AND CASP8AP2 EXPRESSION IN ADULT ACUTE B-CELL LYMPHOBLASTIC LEUKEMIA PATIENTS | ||
| ALEXMED ePosters | ||
| Article 1, Volume 6, Issue 2, April 2024, Pages 39-40 | ||
| Document Type: Preliminary preprint short reports of original research | ||
| DOI: 10.21608/alexpo.2024.296944.1865 | ||
| Authors | ||
| rania shafik swelem1; Ahmed Shehata Abdelrahman2; salma alaa eldin imbaby3; Nourane Khaled Abdellah Ahmed* 4 | ||
| 1clinical pathology, faculty of medicine, alexandria university | ||
| 2Departments of internal medicine, Hematology, Faculty of Medicine, University of Alexandria, Egypt | ||
| 3Department of Physical Medicine, Rheumatology and Rehabilitation, Faculty of medicine, Alexandria university, Egypt. | ||
| 4Department of Clinical and Chemical Pathology, Alexandria University, Egypt. | ||
| Abstract | ||
| Acute lymphoblastic leukemia is a clonal proliferationof the lymphocyte precursor cells. Both T-cell and B-cell precursors can give rise to ALL.Molecular markers have made a breakthrough in ALL after proving to be important in disease pathogenesis and as therapeutic targets. The C-terminal binding protein 2 (CTBP2) is a transcriptional repressor that was reported to correlate with tumorigenesis and progression in several cancers. Down-regulation of CTBP2 mediated by some tumor suppressors results in p53-independent apoptosis and reduced tumor cell migration and invasion. Caspase-8 associated protein 2 (CASP8AP2) has been recognized as a key mediator of apoptosis. Previous studies conducted stated that low expression of CTBP2 and CASP8AP2 gene was associated with relapse in childhood B-ALL. Yet, minimal studies have been conducted to evaluate the prognostic role of CTBP2 and CASP8AP2 gene expression in adult B-ALL. AIM: The aim of this study was to investigate the expression of CTBP2 and CASP8AP2 genes in newly diagnosed cases of acute B-cell lymphoblastic leukemia in adult patients in relation with other clinicopathological parameters. | ||
| Keywords | ||
| LEUKEMIA; CTBP2; CASP8AP2 | ||
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