The Relations between Cadmium, Zinc and Oxidative stress in Oligoasthenozoospermic Men | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 19, Volume 29, Issue 1, June 2009, Pages 245-258 PDF (190.68 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2009.36344 | ||
| Authors | ||
| Marwa Ahmed* 1; Dalia Abd El-Aziz2 | ||
| 1Physiology Department , Faculty of Medicine, Assiut University | ||
| 2Dermatology & Andrology Department, Faculty of Medicine, Assiut University | ||
| Abstract | ||
| Background: Cadmium (Cd) has been found to accumulate in male reproductive organs and induce male reproductive toxicity in several animal species. Objective: To study the levels of Cadmium and Zinc in blood and seminal plasma of oligoathenozoospermic men and to investigate their possible role and their relation to oxidative stress in pathophysiology of oligoathenozoospermia. Study Design: Blood and seminal plasma were collected from thirty primary infertile males with oligoasthenozoospermic, and 30 control subjects. Cadmium (Cd), zinc (Zn), malondialdehyde (MDA) and superoxide dismutase (SOD) activity were estimated in all samples. Results: The serum and seminal concentrations of Cd and MDA of oligpasthenozoospermic group were significantly higher than those of control groups. Levels of blood and seminal plasma of Zn and SOD activity of infertile men were significantly lower than those of control group. The seminal plasma levels of Cd of oligoathenozoospermic group were correlated positively and significantly with MDA levels in seminal plasma. However, there were significant negative correlations between seminal plasma levels of Cd and seminal levels of Zn and seminal SOD activity ,sperm count and sperm motility .There were inverse correlations between seminal plasma levels of MDA and SOD activity, sperm count and sperm motility in oligoathenozoospermic group. The results also shows that there was a positive and significant correlation between the seminal SOD activity and sperm motility in infertile men. Seminal plasma levels of Zinc were negatively and significantly correlated with sperm motility of oligoathenozoospermic group. Conclusion: Cadmium may have adverse impacts on semen quality and male reproductive health. The pathophysiological mechanism of high Cadmium levels in oligoathenozoospermic men is probably through induction of oxidative stress. Lowered levels of zinc may contribute to infertility through its significant effects on semen motility. There is competitive mechanism of interaction between Zn in relation to Cd in oligoathenozoospermic men | ||
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