Investigating the Toxicity of Some Pharmaceutical Compounds on The 3rd Instar Larvae of The Culex pipiens molestus Forskal | ||
| Egyptian Journal of Veterinary Sciences | ||
| Volume 56, Issue 7, July 2025, Pages 1613-1620 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejvs.2024.283102.2014 | ||
| Authors | ||
| Aulfat Tahseen Yaseen* ; Muneef A. Mustafa | ||
| Department of Biology, College of Science, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| The 3rd-instar Culex pipiens molestus Forskal larvae were used in this study to evaluate the toxicity of different concentrations of some drugs (niclosamide, isoniazid, piperazine, sulfasalazine, and 4-amino antipyrine). The mosquito mortality percentages were calculated using a gradient concentration of the examined medicines to estimate the acute toxicity testing. A concentration of 15 ppm of niclosamide on the 4th day of the experiment had a deadly impact on a mosquito's third instar larvae, resulting in a 100% death rate. The LC50 value of the niclosamide solution was found to be 23.11. On the 2nd day of treatment, however, 140 ppm of isoniazid resulted in 100% larval mortality. The LC50 value of the isoniazid solution was found to be 206.16. Practically all of the treated larvae were killed by the 300 ppm dosage of piperazine on the 3rd day of the treatment. The LC50 value of the piperazine solution was found to be 504.38. A concentration of 400 ppm of sulfasalazine on the 5th day of the experiment had a deadly impact resulting in a 100% death rate on mosquito's larvae. The LC50 value of the sulfasalazine solution was found to be 626.59. During the 3rd day of the study, a concentration of 2000 ppm of 4-aminoantipyrine caused 100% fatality in the larvae. The LC50 value of the 4-aminoantipyrine solution was found to be 3656.57. The effect of drug solutions as an inhibitor of egg-laying was that the concentrations used to kill third-instar larvae of mosquitoes had an effect of preventing egg-laying by 100% at all concentrations except for the niclosamide solution, which gave an egg-laying prevention percentage of 54.2, 43.4, 26.0, and 12.4 for concentrations 15, 12, 9, and 7 ppm, respectively. The concentrations used in the experiment to kill the third instar of mosquitoes were reduced to reach the concentrations at which female mosquitoes could lay eggs. | ||
| Keywords | ||
| Culex; Drugs; Larvae; Mosquitoes; Toxicity | ||
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