Therapeutic Effect Of Methanolic Extract Of Parsely and Celery Leaves in experimentally | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 62, Issue 4, October 2016, Pages 83-94 PDF (4.51 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2016.365838 | ||
| Authors | ||
| El-said Awad* ; M Warda; J Fayek | ||
| Biochemistry and Chemistry of Nutrition Department Fac of Vet. MED, Cairo University | ||
| Abstract | ||
| Gout ts a serious disease affecting men and characterized by abnormal high level of uric acid in the body, resulting in the formation and deposition of urate crystals in the joint and other tissues causing painful inflammation. The present study was conducted to investigate the effect of parsley and celery leaves extract on experimentally oxonated - hyperuricemic rats. For this purpose fifty male albino rats were categorized into five equal groups (N=10/group) as follows: group I (Negative control group), group II (Pot Oxonate Hyperuracemic group), group III (Hyperuracemic rats rested with parsley extract), group IV (Hyperuracemic rats treated with celery extract), group V (Hyperuracemic rats treated with allopurinol). Allopurinol was used as a hypouracemic standard drug. The results revealed that oxonated hyperuracemic rats (group II), characterized by a significant increase in the concentration of uric acid, creatinine, urea, activities of ALT, AST and ALP in serum. In addition to significant changes in the antioxidant damage of hepatic tissue through increased levels of lipid peroxidation (MDA), and decreased in reduced glutathione (GSH) concentration, glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities. On the other hand administration of parsley and celery leaves extracts modulated significant the alterations in most of the previously mentioned parameters into normal ranges. In conclusion, our finding suggests that, the two selected medical plants (parsley and celery leaf extracts) can be considered as a potential source of antioxidants and xanthine oxidase inhibitory agent that might be helpful in the prevention and treatment of gout. | ||
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