Salama, S., Rashad, S., Elgendy, A., Agamy, H., El Bably, M. (2024). A STUDY OF SERUM HEPCIDIN LEVEL IN RELATION TO CLINICAL ACTIVITY INDICES AND COMPLETE BLOOD PICTURE PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS. test, 75(2), 575-585. doi: 10.21608/asmj.2024.268217.1220
Sherihan M Salama; Samia M Rashad; Aya M Elgendy; Heba S Agamy; Mona M El Bably. "A STUDY OF SERUM HEPCIDIN LEVEL IN RELATION TO CLINICAL ACTIVITY INDICES AND COMPLETE BLOOD PICTURE PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS". test, 75, 2, 2024, 575-585. doi: 10.21608/asmj.2024.268217.1220
Salama, S., Rashad, S., Elgendy, A., Agamy, H., El Bably, M. (2024). 'A STUDY OF SERUM HEPCIDIN LEVEL IN RELATION TO CLINICAL ACTIVITY INDICES AND COMPLETE BLOOD PICTURE PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS', test, 75(2), pp. 575-585. doi: 10.21608/asmj.2024.268217.1220
Salama, S., Rashad, S., Elgendy, A., Agamy, H., El Bably, M. A STUDY OF SERUM HEPCIDIN LEVEL IN RELATION TO CLINICAL ACTIVITY INDICES AND COMPLETE BLOOD PICTURE PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS. test, 2024; 75(2): 575-585. doi: 10.21608/asmj.2024.268217.1220

A STUDY OF SERUM HEPCIDIN LEVEL IN RELATION TO CLINICAL ACTIVITY INDICES AND COMPLETE BLOOD PICTURE PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS

Ain Shams Medical Journal
Volume 75, Issue 2, June 2024, Pages 575-585    PDF (426.26 K)
Document Type: Original Article
DOI: 10.21608/asmj.2024.268217.1220
Authors
Sherihan M Salama* 1; Samia M Rashad2; Aya M Elgendy3; Heba S Agamy4; Mona M El Bably2
1Physical medicine, rheumatology and rehabilitation, faculty of medicine, Ain Shams university, Cairo, Egypt
2Physical Medicine, Rheumatology and Rehabilitation. Faculty of Medicine, Ain Shams University. Khalifa El-Maamon st, Abbasiya sq. Cairo, Egypt
3Internal medicine and Rheumatology. Faculty of Medicine, Ain Shams University. Khalifa El-Maamon st, Abbasiya sq. Cairo, Egypt.
4Clinical pathology. Faculty of Medicine, Ain Shams University. Khalifa El-Maamon st, Abbasiya sq. Cairo, Egypt.
Abstract
Background: Rheumatoid arthritis (RA) is a chronic auto-immune-mediated inflammatory arthritis that affects around one percent of the human population. One of the common comorbidities encountered in rheumatoid patients is anemia. Hepcidin being one of the acute-phase reactant proteins, it acts as a homeostatic regulator of iron metabolism and as an inflammatory mediator as well. Aim of The Work: This study aims to evaluate the value of measuring serum hepcidin levels in patients with rheumatoid arthritis and its relationship with clinical disease activity and blood parameters.
Methods: fifty RA patients underwent full medical assessment with the evaluation of DAS-28 score, laboratory tests including CBC, ESR, rheumatoid factor and anti-CCP, serum ferritin and serum iron, and serum hepcidin level.
Results: Our results showed that there was a statistically significant correlation between inflammatory markers and serum hepcidin level, as well as a positive correlation between the degree of disease activity measured by DAS 28 score with serum hepcidin level. Conclusion: We concluded from our study that serum hepcidin can be used to assess the disease activity in rheumatoid arthritis patients and rheumatoid-related anemias as well.
 
Keywords
Rheumatoid arthritis; hemoglobin; anemia; hepcidin; anemia of chronic disease
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