Long non-coding RNA HOTAIR as diagnostic marker in dermatological autoimmune diseases: A systematic review | ||
| Fayoum University Medical Journal | ||
| Volume 13, Issue 3, April 2024, Pages 40-48 PDF (844.28 K) | ||
| Document Type: Full Length research Papers | ||
| DOI: 10.21608/fumj.2024.265276.1310 | ||
| Authors | ||
| Emad Adel Atta Allah* 1; Amal Talaat Abd El-Rahman2; Nesreen Mohamed Mahmoud Aboraia3; Azza Mohamed Elamir4 | ||
| 1Dermatology and Andrology department Faculty of Medicine Fayoum University. | ||
| 2Dermatology, Faculty of medicine, Minia University | ||
| 3Assistant professor of dermatology , STDs and Andrology Faculty of medicine Fayoum university . | ||
| 4medical biochemistry and molecular biology department, faculty of medicine, fayoum university | ||
| Abstract | ||
| Background: Damage to different organs is caused by aberrant responses from the innate and adaptive immune systems in autoimmune disorders, which encompass a variety of issues. The cause of autoimmune diseases is a very complex and poorly understood phenomenon. Patients and methods: Our search result contained original research from PubMed, Medline, and EMBASE. There were no review papers included. Studies must have published at least one lncRNA that they discovered through experimentation. Results: Psoriasis, alopecia areata, systemic sclerosis, and melanoma were among the autoimmune dermatological conditions that were mentioned. With the exception of alopecia areata, where expression was downregulated relative to control, HOTAIR expression was significantly higher in cases of autoimmune dermatological diseases than in the control group in all cases. Conclusion: We can conclude that the long non-coding RNA known as HOTAIR functions as a diagnostic marker for skin autoimmune diseases and it also might play a role in their pathogenesis. | ||
| Keywords | ||
| Long non-coding RNA; HOTAIR; Marker; Autoimmune diseases | ||
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