Antibodies to HIV-1 specific antigens in HBV and HCV coinfected patients in Warri, Nigeria | ||
| Microbes and Infectious Diseases | ||
| Article 9, Volume 6, Issue 1, February 2025, Pages 102-109 PDF (221.95 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2024.298120.2013 | ||
| Authors | ||
| Mathew Folaranmi Olaniyan1; Kemi Felicia Ajiboye2; Tolulope Busayo Olaniyan1; Odekunle Bola Odegbemi* 1, 3 | ||
| 1Medical Laboratory Department, Edo State University, Uzairue, Edo State, Nigeria | ||
| 2Public Health Department, Torrens University, Adelaide, Australia | ||
| 3Medical Laboratory Department, Nigerian Navy Hospital, Warri, Delta State, Nigeria | ||
| Abstract | ||
| Background: Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), and Hepatitis C Virus (HCV) are critical global public health issues, particularly in resource-limited settings like Warri, Nigeria, where healthcare systems face significant challenges. This study investigates the prevalence of antibodies to HIV-1-specific antigens in HBV and HCV-coinfected patients in Warri. Methods: Utilizing a cross-sectional design, 350 HIV-positive individuals were systematically sampled, and their blood samples were analyzed using ELISA and Western blot techniques. Results: Among the participants, 17.7% were coinfected with HBV and 10.9% with HCV. A high prevalence of antibodies to HIV-1 gp120, gp41, and p24 was observed, with no significant differences between the HBV and HCV coinfected groups (p > 0.05). Conclusion: These findings highlight the impact of HBV and HCV coinfections on the humoral immune response to HIV-1. Our study underscores the need for integrated diagnostic and therapeutic strategies to improve patient care in resource-limited settings. Understanding these interactions is crucial for developing effective management approaches for patients with HIV, HBV, and HCV coinfections. | ||
| Keywords | ||
| HIV-1; coinfection; hepatitis; Warri; Humoral immune response | ||
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