Abdelazeema, M., Koura, R., Abdeltawab, W., Rady, S. (2024). Association of dyslipidemia to asymptomatic sensorineural hearing loss in Patients with systemic lupus erythematosus. test, 5(3), 35-49. doi: 10.21608/ejmr.2022.108361.1171
Mervat I. Abdelazeema; Rabab A. Koura; Weasam R.R. Abdeltawab; Shaimaa A.K. Rady. "Association of dyslipidemia to asymptomatic sensorineural hearing loss in Patients with systemic lupus erythematosus". test, 5, 3, 2024, 35-49. doi: 10.21608/ejmr.2022.108361.1171
Abdelazeema, M., Koura, R., Abdeltawab, W., Rady, S. (2024). 'Association of dyslipidemia to asymptomatic sensorineural hearing loss in Patients with systemic lupus erythematosus', test, 5(3), pp. 35-49. doi: 10.21608/ejmr.2022.108361.1171
Abdelazeema, M., Koura, R., Abdeltawab, W., Rady, S. Association of dyslipidemia to asymptomatic sensorineural hearing loss in Patients with systemic lupus erythematosus. test, 2024; 5(3): 35-49. doi: 10.21608/ejmr.2022.108361.1171

Association of dyslipidemia to asymptomatic sensorineural hearing loss in Patients with systemic lupus erythematosus

Egyptian Journal of Medical Research
Volume 5, Issue 3, July 2024, Pages 35-49    PDF (631.99 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.108361.1171
Authors
Mervat I. Abdelazeema1; Rabab A. Koura2; Weasam R.R. Abdeltawab3; Shaimaa A.K. Rady* 1
1Rheumatology and Rehabilitation Department, Faculty of Medicine, Beni-Suef University, Egypt
2Audiology Department, Faculty of Medicine, Beni-Suef University, Egypt
3Rheumatology and Rehabilitation Department, Fayoum General Hospital, Egypt
Abstract
Background: Sensorineural hearing loss can be the first manifestation in systemic lupus erythematosus patients. It  has been described to occur  more frequently in females than  in males. Aim of the work: To detect asymptomatic sensorineural hearing loss (ASNHL) in patients with Systemic Lupus Erythematosus (SLE)and to find its relation to lipid profile and other disease parameters. Patients and Methods: a case control study conducted on fifty SLE patients (3 males and 47 females)and twenty matched healthy controls (2males and 18 females). SLE disease activity index (SLEDAI) and systemic lupus international collaborative clinics damage index (SLICC DI) scores were done. All patients were subjected to clinical and laboratory investigations. Lipid profile was done for patients and controls.  Otoacoustic emission test, Audiometry, were done for patients and controls. Results: The mean age of the patients was (28.46 ± 8.8) and the disease duration was(7.12 ±6.33) years. Triacylglycerol(TAG), Cholesterol, Low density lipoprotein (LDL) cholesterol were significantly higher in SLE patients compared to controls (p= 0.034, 0.005, 0.002respectively). ASNHL was observed in 10 SLE patients (20%). TAG, Cholesterol, LDL cholesterol were significantly higher in patients with SNHL compared to patients without SNHL (p=0.022, 0.038, 0.020 respectively). Oral ulcers, serositis were significantly more prevalent in patients with SNHL compared topatients without SNHL (p=0.036,0.034 respectively). Disease activity (SLEADI) and  damage index scores( SLICC DI) were significantly higher in patients with SNHL compared topatients without SNHL (p=0.028, 0.009 respectively).Conclusion: Asymptomatic SNHL was found in minority of SLE patients with an association with high levels of TAG, cholesterol, LDL cholesterol suggesting atherosclerosis as a mechanism.
Keywords
Systemic Lupus Erythematosus; Sensorineural hearing loss; Low density lipoprotein
References

  1. Umare V, Nadkarni A, Nadkar M, Rajadhyksha A, Khadilkar P, Ghosh K, et al. Do high sensitivity C-reactive protein and serum interleukin-6 levels correlate with disease activity in systemic lupuserythematosuspatients?. J Postgrad Med 2017; 63: 92–5.
  2. Mijovic T, Zeitouni A, Colmegna I. Autoimmune sensorineural hearing loss: the otology–rheumatology interface. Rheumatol (Oxford). 2013; 5(52), 780-9.
  3. Ryan AF, Keithley EM, Harris JP. Autoimmune inner ear disorders. CurrOpinNeurol 2001; 1(14): 35-40.
  4. Abbasi M, Yazdi Z, Kazemifar AM &Bakhsh ZZ. Hearing loss in patients with systemic lupus erythematosus. Glob J Health Sci 2013; 5(5): 102.
  5. Gad G I, Abdelateef H. Function of the audiovestibular system in children with systemic lupus erythematosus. Curr Allergy Rsthma Rep 2014; 14(7): 446.‏
  6. Dashty M, Motazacker MM, Levels J, de Vries M, Mahmoudi M, Peppelenbosch MP et al. "Proteome of human plasma very low-density lipoprotein and low-density lipoprotein exhibits a link with coagulation and lipid metabolism". ThrombHaemost2014; 111: 518–30.
  7. Krauss R. M. Lipoprotein subfractions and cardiovascular disease risk. CurrOpinLipidol 2010; 21(4): 305–11.
  8. Chang IJ, Kang CJ, Yueh CY, Fang KH, Yeh RM &Te Tsai Y. The relationship between serum lipids and sudden sensorineural hearing loss: a systematic review and meta-analysis. PLoS One 2015; 4(10): e0121025.
  9. Kiss E, Fazekas B, Tarr T, Muszbek L, Zeher M, Szegedi G. Lipid profile in patients with systemic lupus erythematosus, with special focus on lipoprotein (a) in lupus nephritis. Orvosihetilap. 2004; 145(5): 217-22.
  10. Bahrehmand F, Vaisi-Raygani A , Ahmadi R, Kiani A, Rahimi Z, Tavilani H et al. Paraoxonase (PON1) 55 polymorphism and association with systemic lupus erythematosus. Iran J Allergy Asthma Immunol 2013; 211-19.‏
  11. ‏Juárez-Rojas J G, Medina-Urrutia A X, Posadas-Sánchez R, Jorge-Galarza E, Mendoza-Pérez E, Caracas-Portilla N, et al. High-density lipoproteins are abnormal in young women with uncomplicated systemic lupus erythematosus. Lupus 2008; 17(11): 981-7.‏
  12. Hahn B H, Grossman J, Ansell B J, Skaggs B J, McMahon M. Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis. Arthritis  res  ther 2008; 10(4): 213.‏
  13. Gamal S M, Fawzy S M, Abdo M, Elgengehy F T, Ghoniem S et al.Immunological profile and dyslipidemia in Egyptian Systemic Lupus Erythematosus patients. Egypt Rheumatol 2017;89-92: 1110-64.
  14. Petri Michelle, Orbai. Derivation and Validation of Systemic Lupus International Collaborating Clinics Classification Criteria for Systemic Lupus Erythematosus Arthritis Rheum2012; 64(8) :2677.
  15. Bombardier C, Gladman DD, Urowitz MB, Caron D & Chang CH Derivation of the SLEDAI. A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 1992; 35: 630–40.
  16. Gladman DD, Goldsmith CH, Urowitz MB, Bacon P, Fortin P, Ginzler E, et al. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index for Systemic Lupus Erythematosus. International Comparison.JRheumatol2000; (2):373-6.
  17. Soliman S, Fathalla A &Shehat M. Development of Arabic staggered spondee words.(SSW) test: In proceeding of 8th Ain Shams Med Congress1985; 2: 1220-46.
  18. Soliman S. Speech discrimination audiometry using Arabic phonetically- balanced words. Ain Shams Med J 1976; 27: 27-30.
  19. Narne V K, Prabhu P P&Chatni S. Time–frequency analysis of transient evoked-otoacoustic emissions in individuals with auditory neuropathy spectrum disorder. Hear res 2014; 313: 1-8.‏
  20. Riera J L , Maliandi M R    , Musuruana J L    , Cavallasca J A.  Sudden sensorineural hearing loss in systemic lupus erythematosus and  anti-phospholipid syndrome: A  Clinical review. Curr Rheumatol Rev 2020 ;16(2):84–91.
  21. Lin C, Lin SW, Weng SF & Lin YS,Risk of sudden sensorineural hearing loss in patients with systemic lupus erythematosus: a population-based cohort study. Audiol Neurootol 2013; 2(18): 95-100.
  22. Ferrari ALV, Calonga L, Lapa AT, Postal M, Sinicato NA, Peliçari KO, et al. Low-Density Lipoprotein Cholesterol Is Associated With Asymptomatic Sensorineural Hearing Loss in Patients With Systemic Lupus Erythematosus J ClinRheumatol 2016; 6(22): 312-5.
  23. Roverano S, Cassano G, Paira S, Chiavarini J, Graf C, Rico L, et al. Asymptomatic sensorineural hearing loss in patients with systemic lupus erythematosus. ClinRheumatol Journal 2006; 5(12):217-20.
  24. Dall'Era M, Cisternas MG, Snipes K, Herrinton LJ, Gordon C, Helmick CG. The incidence and prevalence of systemic lupus erythematosus in San Francisco County, California. The California lupus surveillance project. Arthritis rheumatol 2017; 10(69): 1996-2005.
  25. Urowitz MB, Gladman D, Ibanez D, Fortin P, Sanchez-Guerrero J, Bae S, et al. Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort. Lupus 2007; 9(16): 731-5.
  26. Batuecas-Caletrío A, del Pino-Montes J, Cordero-Civantos C, Calle-Cabanillas MI & Lopez-Escamez JA. Hearing and vestibular disorders in patients with systemic lupus erythematosus. Lupus 2013; 5(22): 437-42.
  27. Mokbel A N, Hassan S Z,Zohdi M I, ElShennawy A M, Auditory disorders in patients with systemic lupus erythematosus: Relation to clinical parameters. EgyptRheumatol (2014); 36, 117-24: 1110-64.
  28. Gomides A P M, Do Rosário E J, Borges H M, Gomides H H M, de Pádua P M, Sampaio-Barros P D. Sensorineuraldysacusis in patients with systemic lupus erythematosus. Lupus 2007; 16(12): 987-90.
  29. Andreeva VA, Assmann KE, Adjibade M, Lemonge C &Hercberg S. Dyslipidemia as a potential moderator of the association between hearing loss and depressive symptoms. J Nutr Health Aging 2017; 10(21):1291-8.
  30. Weng T, Devine EE, Xu H, Yan Z, Dong P. A clinical study of serum lipid disturbance in Chinese patients with sudden deafness. Lipids Health Dis 2013; 1(12): 95.
  31. Odeh O, Kuti M, Fasunla A, Nwaorgu O. Sensorineural hearing loss and dyslipidemia: is there any relationship. West Afr J Med 2015; 34: 27-31.
Statistics
Article View: 304
PDF Download: 169