PHARMACOKINETICS OF CEFQUINOME IN CAMELS | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 57, Issue 4, October 2009, Pages 783-792 PDF (2.95 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2011.368065 | ||
| Author | ||
| A Al Taher | ||
| college of Veterinary Medicine and Animal Resources, King Faisal University | ||
| Abstract | ||
| The Pharmacokinetic characters of cefquinome were studied in camels following single intramuscular administration of 1 mg kg-1 b.wt. Cefquinome concentrations in serum were determined by microbiological assay using Micrococcus luteus (ATCC 9341) as test organism. After intramuscular administration, the mean peak serum concentrations (Cmax) was 1.23 µg ml-1 and achieved after (tmax) 4.25 hour. The absorption half life (t ½(ab)) was 4.35 h and the elimination half-life (t ½ (el)) was 10.24 h. The mean residence time (MRT) was 16.74 h and area under curve from zero time to infinity (AUC0-∞) was 20.37 µg mL-1 h-1. The serum concentrations of cefquinome along 24 hours post-injection in this study was exceeding the MICs of different susceptible micro-organisms responsible for serious disease problems. These findings indicate the suitability of successful use of this antibiotic in camels. A recommended single daily dose of 1 mg kg-1 of cefquinome given intramuscularly can achieve quite therapeutic concentrations in serum, that exceeding the minimal inhibitory concentrations against different susceptible pathogens. | ||
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