Teratogenic effects of abamectin in rats | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 59, Issue 4, October 2011, Pages 299-305 PDF (1023.03 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2011.368352 | ||
| Authors | ||
| zaghloul H* 1; El-Ballal S2; Morgan M3; El Bialy E4 | ||
| 1Theriogenology, Departments, Faculty of Veterinary Medicine, Minufiya University, El-Sadat city branch, Egypt | ||
| 2Pathology, Departments, Faculty of Veterinary Medicine, Minufiya University, El-Sadat city branch, Egypt | ||
| 3toxicology and Forensic Medicine Department, Faculty of Veterinary Medicine, Cairo University, Egypt | ||
| 4Forensic Medicine and Toxicology, Departments, Faculty of Veterinary Medicine, Minufiya University, El-Sadat city branch, Egypt | ||
| Abstract | ||
| The teratogenic effects of abamectin pesticide on pregnant rats were studied following oral administration of 2.85, 1.42 and 0.72 mg/ kg bw (1/10, 1/20 and 1/40 of the oral LD50, respectively) during the organogenesis period. Treatment with abamectin did not influence the reproductive status (number of uterine implants, resorptions, live and dead fetuses per litter) at all dosage levels. However, it caused significant increase in the percentages of morphological, visceral and skeletal malformations in rat fetuses on exposure to the two high doses compared to control. In addition , abamectin induced different pathological alterations in the placentae and fetal organs in a dose-related manner. | ||
| Keywords | ||
| Abamectin; teratogenic; fetuses; placenta; malformations; rat | ||
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