A Study on the Protective Effects of Zinc Sulphate, Nicotinic Acid and Nigella Sativa on Alcohol Induced Gastric Lesion in Male Albino Rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 7, Volume 28, Issue 1, June 2008, Pages 77-90 PDF (210.46 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2008.36837 | ||
| Authors | ||
| Mahmoud EI-Gharieb* 1; Thanaa El-Masry2 | ||
| 1Department of Physiology, Faculty of Medicine , Tanta University | ||
| 2Department of Pharmacology, Faculty of Pharmacy, Tanta University | ||
| Abstract | ||
| The present study was conducted to study the protective effects of zinc suiphate (ZnS), nicotinic acid (NA) and Nigella sativa on the alcohol induced gastric lesion in male albino rats. The study was carried out on (48) adult male albino rats weighing 200-250 gms. The rats were divided into two equal groups, then. Each group was subdivided into four equal subgroups. Group (A): The normal rats which are subdivided into: subgroup (l): control group subgroup (2): the rats were intraperitoneally injected by zinc sulphate subgroup (3) the rats were intraperitoneally injected by nicotinic acid and subgroup (4) the rats were orally administrated Nigella Sativa oil daily for two weeks. Group (B) The rats were subdivided into: subgroup (l): rats were administrated ethanol 40% orally for two weeks, subgroup; (2): the rats were administrated ethanol 40% orally and intraperitoneally injected by zinc sulphate, subgroup (3) the rats were administrated ethanol 40% oral!y and intraperitoneally injected by nicotinic acid and subgroup (4) the rats were administrated by ethanol 40% orally with Nigella Sativa oil orally daily for two weeks. After the last dose of eachgroup, the animals were left for one hour then anaesthetized by ether. The gastric secretion was collected in the acute rat fistula. The abdomen was incised and both the stomach and the duodenum were exposed. The gastric secretion was collected for the analysis and sections were taken for histological examination. The results showed significant increase of gastric mucin content, and glutathione and significant decrease in the volume of the gastric secretion, peptic activity, free acidity and gastric histamine content in ethanol induced gastric lesion with either zinc sulphate, nicotinic acid and Nigella Sativa oil. histopathological picture showed improvement of hemorrhage, edema and increase in the mucus layer thickness and regeneration of the gastric mucosal erosion. It is recommended to increase the administration of zinc sulphate, nicolinic acid and Nigella Sativa to patients with gastric ulcer. | ||
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