Influence of Acidifiers on Pharmacokinetics And Tissue Residues of Lincomycin in Healthy Broiler Chickens | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 60, Issue 1, January 2014, Pages 95-110 PDF (7.09 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2014.368817 | ||
| Authors | ||
| Aziza Amer; S Youssef; T Abo Sreea* | ||
| pharmacology Department, faculty of Veterinary Medicine, Cairo University PO Box 12211, Giza, Egypt. | ||
| Abstract | ||
| in this study we investigated the influence of acidifiers (Gallimix) on the disposition Kinetics and tissue residues of Lincomycin following single i.v and oral administrations (20 mg/kg b.wt). Lincomycin serum concentration was determined by microbiological assay method. following i.v injection, Lincomycin serum concentration versus time curve was best fitted a 2-comparment open model. It is clear that there is no significant differences in the values of distribution rate constant (α) and distribution half-life (t1/2a) of Lincomycin following single oral administration of Lincomycin in chickens fed acidifiers containing ration (lppm), the peak concentration (Cmax) was 5,63±1.42 mg/ml and was achieved at Tmax (0.62±0.23) which is significantly lower (Cmax) and shorter Tmax than chickens fed on free acidifiers. The calculated bioavailability (F %) was 54.99±7.54% which is significantly lower than the corresponding one (80.13±4.68%) in chickens fed on acidifiers free ration. The average value of protein binding percentage of Lincomycin to chicken’s serum proteins was 14.5±1.26%. Following residue studies the obtained results revealed that Lincomycin was found widely distributed in chickens fed acidifiers free ration. In conclusion: concomitant administration of Lincomycin and Gallimix in broiler chickens must be not recommended as the interaction between them significantly reduces Lincomycin blood concentration and tissue distribution which consequently decreases its therapeutic efficacy. | ||
| Keywords | ||
| Acidifier; Lincomycin; Kinetics; Residues; Bioavailability | ||
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