EFFECT OF THE ANTIPARASITIC DRUG “CLOSANTEL” ON FETAL DEVELOPMENT AND SOME BIOCHEMICAL PARAMETERS IN RABBITS | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 50, Issue 2, April 2002, Pages 299-310 PDF (3.65 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2002.369256 | ||
| Author | ||
| AMANYE YOUSSEF* | ||
| Animal Health Research Institute, Dokki, Giza. | ||
| Abstract | ||
| The teratogenic effect of closantel subcutaneously injected in doses of 5 and 10 mg / kg. b. wt. during the period of organogenesis was studied in rabbits. Moreover its effect on some serum bio- chemical constituents was studied. Closantel de- creased significantly fetal body weight and percentage of living foetuses. Dilatation of lateral ventricles of the brain, pericarditis, intrathoracic haemorrhage, hypoplasia of the lung, dilatation of renal pelvis, spinal bifida incomplete ossification of skull bones and absence of some sternbrae and phalanges were reported. Closantel increased significantly the activities of Aspartate aminotransferase (AST), Alanine ami- notransferase (ALT) and Alkaline phosphatase (ALP). It also increased the concentration of serum total bilirubin, urea and creatinine but de- creased the level of total protein. | ||
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