BEHAVIOURAL AND HISTOPATHOLOGICAL ALTERATIONS INDUCED BY DIFFERENT DOSES OF NON STEROIDAL ANTI-INFLAMMATORY DRUG (INDOMETHACIN) IN RATS | ||
| Veterinary Medical Journal (Giza) | ||
| Volume 52, Issue 4, October 2004, Pages 517-533 PDF (6.87 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/vmjg.2004.369310 | ||
| Authors | ||
| KAWKAB AHMED* 1; ABEER ABD EL RAZEK2 | ||
| 1Dept. of Pathology, Faculty of Veterinary Medicine, Cairo University. | ||
| 2Dept. of Animal hygiene and Management, Faculty of Veterinary Medicine, Cairo University. | ||
| Abstract | ||
| A total of eighty albino adult rats (64 females and 16 males) were divided into four groups each contain 16 females and 4 males. The first group (I) was served as control untreated group; the other three groups (II, III and IV) were daily intramuscularly injected with different doses of indomethacin (0.5, 1 and 2 mg/kg body weight) respectively for two weeks after one-week post service. The animals subjected to behavioural, haematological and histopathological studies. Behavioural measurements revealed statistical differences among the groups for the maternal behaviour and the body weight of pups, however, there are no statis tical differences between the groups for the physical performance of the pups. Haematological examination revealed significant changes in the measured haematological parameters of rats treat- ed with high dose of indomethacine (group IV). Microscopical examination of liver revealed prominent hepatocellular vacuolations, portal infiltration with mononuclear leucocytic cells as well as multifocal areas of hepatic necrosis associated with mononuclear cells infiltration. The kidney showed different necrobiotic changes, focal interstitial nephritis as well as marked shrunken and atrophied glomeruli. Moreover, the brain showed marked meningeal hemorrhage and congestion. Examined testis revealed congestion of intertubular blood vessels together with marked destruction and necrosis of spermatogoneal and sertoli cells lining seminiferous tubulės. In conclusion, This study claimed that the usage of indomethacin could alter the expression and delays the rapid onset of maternal behaviour as well as induced deleterious histopathological changes. | ||
| Keywords | ||
| Non Steroid anti; inflammatory drugs; indomethacin fi behaviour; haematology histop; athology; rats | ||
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