A Potential Role for Ghrelin in Partial Sleep Deprivation Mediated Immunomodulation | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 3, Volume 28, Issue 2, December 2008, Pages 23-44 PDF (306.83 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2008.37019 | ||
| Authors | ||
| Mary Youssef* 1; Mariam Hanna2; Laila Rashed3 | ||
| 1Department of Physiology , Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 2Department of Clinical Pathology , Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 3Department of Medical Biochemistry , Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| Abstract | ||
| The mechanisms through which sleep deprivation leads to impairment of the immune system are poorly elucidated. The objectives of the present work were to study the effects of the common, real-life situation - partial sleep deprivation (PSD) on some immune aspects particularly the serum level of interleukin-6 (IL-6) which is implicated to mediate sleep-immune interaction and to investigate the impact of ghrelin, a growth hormone releasing and orexigenic hormone, expressed by the stomach and peripheral blood mononuclear cells (PBMCs) on such interaction. Knowledge gained from basic research into sleep in animals has led to marked advances in the understanding of human sleep, with important diagnostic and therapeutic implications and neurobiological studies of sleep deprivation that require invasive procedures are facilitated by the development of animal models. Short-term PSD (7 days) and long-term PSD (14 days) were associated with an increase in total leukocytes, significant reduction in the proinflammatory cytokine IL-6 and a progressive increase in ghrelin mRNA expression by both the stomach and PBMCs compared to control group. Furthermore, a significant negative correlation was found between the level of IL-6 and the expression of ghrelin by PBMCs and stomach. Interestingly, recovery sleep for 4 days had significantly increased the levels of IL-6 and partially decreased the abnormalities in ghrelin expression of sleep-deprivation although it failed to return these parameters to control group levels. Considering the data presented herein, it seems plausible that sleep is a restorative process that is important for the proper secretion of IL-6 and suggest a functional role of ghrelin as a modulator of cytokine production in sleep restriction. | ||
| Keywords | ||
| Sleep; ghrelin; IL-6 | ||
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