Effects of Zinc Acetate on Thioacetamide–Induced Hepatotoxicity in Rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 6, Volume 28, Issue 2, December 2008, Pages 81-90 PDF (156.77 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2008.37034 | ||
| Authors | ||
| Bastway M* ; Hasona A; Abdel Hamid H | ||
| Department of Chemistry, Biochemistry Branch, Faculty of Science, Beni-Suef University, Egypt | ||
| Abstract | ||
| The ameliorative activity of zinc acetate on thioacetamide–induced hepatotoxicity was studied in rats. Forty male rats were divided into four equal groups each of 10. Two groups were controls, one treated withthioacetamide and one with only distilled water. Two groups received zinc acetate and intraperitoneal (IP) thioacetamide (400 mg/kg b.wt.) either before or after administration of zinc acetate. Liver damage was assessed by estimation of plasma concentration of bilirubin and enzymes activities of aspartate aminotransferase, alanine aminotransferase, and hepatic glutathione, MDA levels; SOD and catalase activities. Treatment with zinc acetate signifcantly reduced thioacetamide–induced elevation in plasma bilirubin concentration and enzymes activities. It could be suggested that thioacetamide–induced liver damage in rats could be ameliorated by treatment with zinc acetate. | ||
| Keywords | ||
| Hepatoprotective; Hepatotoxicity; Zinc acetate; Thioacetamide; [MDA] and [SOD] | ||
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