Potentiometric determination of terbinafine hydrochloride antifungal drug in pharmaceutical and biological fluids using ion selective electrodes | ||
| Journal of Basic and Environmental Sciences | ||
| Volume 5, Issue 2, April 2018, Pages 80-92 PDF (573.9 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbes.2024.370408 | ||
| Authors | ||
| Tamer Awad Ali1; Samah M. abdelsabour2; Hassan Eldessouky3; Gehad G. Mohamed4; Yasmin Salah Eldin Elsayed2 | ||
| 1gyptian Petroleum Research Institute (EPRI), 11727, Cairo, Egypt. | ||
| 2National Orgninization of Drug and Research (NODCAR), Giza, Egypt | ||
| 3Chemistry Department, Faculty of Science, Banha University, 13518, Qalubia, Egypt. | ||
| 44 Chemistry Department, Faculty of Science, Cairo University, 12613, Giza, Egypt. 5 Egypt Nanotechnology Center, Elsheikh Zayed, 6th October City, Giza, 12588, Egypt. | ||
| Abstract | ||
| The target of this study is focused on the determination of terbinafine hydrochloride (TFHC) as antifungal drug. A potentiometric method based on modified screen-printed and modified carbon paste ion-selective electrodes was described for the determination of TFHC in different pharmaceutical and biological fluids. It is based on potentiometric titration of TFHC using modified carbon paste (MCPE) and screen-printed (MSPE) as end point indicator sensors. The influences of the paste composition, different conditioning parameters and foreign ions on the electrodes performance were investigated and response time of the electrodes has been studied. The electrodes showed Nernstian response of 57.83±0.75, 59.06±0.69, 56.99±0.92 and 58.75±1.06 mV decade-1 in the concentration range of 3.8×10-7–1×10-2 and 1×10-7–1×10-2 mol L-1 for MCPE (electrode I and II) and MSPE (electrode III and IV), respectively. The electrodes were found to be usable within the pH range of 3.0–9.0 and 4.0-9.0 exhibited a fast response time (about 9 and 11 s), low detection limit of 3.8×10-7 and 1.0 ×10-7 mol L-1, long lifetime (70, 85 and 152, 166 days) for MCPE (electrode I and II) and MSPE (electrode III and IV), respectively. The electrodes were successfully applied for the determination of TFHC in pharmaceutical preparation and biological fluids (urine and serum). The results obtained applying these potentiometric electrodes are comparable with British pharmacopeia. The method validation parameters were optimized and the method can be applied for routine analysis of TFHC drug. | ||
| Keywords | ||
| Terbenafine HCl; pharmaceutical analysis; Potentiometry; Modified screen-printed electrodes; modified carbon paste electrodes | ||
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