Protective and Therapeutic Effect of Green Tea (Camellia sinesis) against Rat Prostate Cancer | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 7, Volume 28, Issue 2, December 2008, Pages 91-102 PDF (184.85 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2008.37040 | ||
| Authors | ||
| Mohamed Heibashy* 1; Amal El-Nahla2; Sherif Saleh3 | ||
| 1Biological Application Department, Nuclear Research Center, Atomic Energy Authority, Egypt | ||
| 2Physiology Department, Faculty of Veterinary Medicine, Suez Canal University | ||
| 3Biochemistry Department, Faculty of Veterinary Medicine, Suez Canal University | ||
| Abstract | ||
| This investigation was conducted to evaluate the protective and therapeutic effect of green tea to ameliorate the deleterious effects of prostate cancer in rats. The obtained data revealed a significant elevation in tumor markers (PSA, TAP and PAP levels) after induction of cancer prostate in rats in comparison with the normal control one. Also, there was a significant decrease in total testosterone, free testosterone and DHEA-S concentrations, but the serum MDA level was increased significantly in rats with cancer prostate as compared with the corresponding levels in control rats. On the other hand, administration of green tea before or/and after induction of prostate cancer in rats led to a considerable improvement in the previous parameters but, their values did not revert to normal level. Any how, the results of the present investigation showed that the green tea when taken before and after induction of cancer prostate gave the prophylactic and therapeutic effects. The underlying mechanisms through which green tea counteracted cancer prostate were discussed. | ||
| Keywords | ||
| green tea; Prostate Cancer; tumor markers; Rats | ||
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