A study of the Effect of Ghrelin on the Regulation of Pancreatic Exocrine Secretion in Male Albino Rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 9, Volume 28, Issue 2, December 2008, Pages 111-120 PDF (169.64 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2008.37045 | ||
| Authors | ||
| Romysa El-Sherbeny* ; Mahmoud El-Gharieb | ||
| Department of Physiology, Tanta University | ||
| Abstract | ||
| The present work was done to investigate the role of ghrelin in the regulation of pancreatic volume and protein secretion in anaesthetized male albino rats. The rats were divided into 4 equal groups: First group Is the control group. Second group: Pancreatic secretion was stimulated by infusion of wheat germ lectin, which is known to be a stimulus of cholicystokinin hormone release, preceded by ghrelin infusion and continued for one hour, this procedure was performed before and after acute subdiaphragmatic vagotomy. Third group: was infused by 2-D-glucose, which acts as central vagal stimulant, preceded by ghrelin infusion and continued for one hour Fourth group: was infused by bethanechol, which is a cholinergic receptor agonist, preceded by ghrelin infusion and continued for one hour. Then the pancreatic secretion was collected after anaesthetizing male albino rat, through a cannula inserted in the common bile duct. The results showed significant increase of the protein content by wheat germ lectin infusion, through stimulation of cholicystokinin which stimulated pancreatic secretion, Ghrelin caused significant inhibition of protein secretion and this inhibition was continued after acute subdiaphragmatic vagotomy, Ghrelin also caused significantinhibition of the pancreatic protein secretion, which caused by central stimulation of vagus nerve by 2-D-glucose infusion. Also, ghrelin showed significantinhibition of the pancreatic protein secretion which caused by bethanechol, that acting as a muscarinic receptor agonist. It is concluded that ghrelin is a potent inhibitor of pancreatic exocrine protein secretion and the mechanism of its action may be directed at the level of the intra pancreatic neurotransmission. | ||
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