Effect of cisplatin on chromosomes of male mice (Mus musculus) | ||
| Journal of Basic and Environmental Sciences | ||
| Volume 5, Issue 4, October 2018, Pages 325-332 PDF (425.43 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbes.2018.370551 | ||
| Authors | ||
| L.M. Abd El-Sadek1; H.I. El-Shaarawy2; M.H. Awwad2 | ||
| 1Zoology Department, Faculty of Science, Benha University, Egypt | ||
| 2Zoology Department, Faculty of Science, Benha University, Egyp | ||
| Abstract | ||
| Cisplatin is an anticancer drug. It is used to treatment of cancer. The present work studies the effect of cisplatin on chromosomes of male mice. 35 healthy adult male Swiss albino mice (Mus musculus) were divided into 7 groups, composed of 5 animals each. The first group was normal (control), the second, third and fourth groups were administered single doses of 5, 10 & 15 mg/kg of cisplatin I.P, respectively. Mice were then anesthetized and killed after one day of cisplatin administration. The fifth, sixth and seventh groups were injected the same doses, but mice were anesthetized and killed after 5 days of cisplatin injection. Bone marrow of mice femurs were prepared the examining of chromosomal aberrations and mitotic index. various chromosomal aberrations were recorded as structural aberrations (deletion, fragmentation, centric fusion, ring, end to end, break and gaps) and as numerical aberration (monosomy and trisomy). Also, the result of this study revealed that cisplatin caused reduction in the mitotic index at various doses. It was found that cisplatin had adverse effect on chromosomes and mitotic index | ||
| Keywords | ||
| Cisplatin; I.P (Intraperitoneally) | ||
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