Effect of estradiol pretreatment on antagonist ICSI cycles outcome: A Randomized controlled trial | ||
| Journal of Reproductive Medicine and Embryology | ||
| Article 6, Volume 1, Issue 2, July 2024, Pages 107-117 PDF (347.65 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jrme.2024.303060.1014 | ||
| Authors | ||
| Sherif Anis* ; Hesham M. Adel; Eman kassem; Tarek Tappozada | ||
| Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt. | ||
| Abstract | ||
| Background: It was thought that using oral contraceptives or GnRH agonists as a pre-treatment for synchronization of multi-follicular growth and enhancement of COH outcomes offers a higher physiological possibility. Objective: Investigate whether pretreatment with E2 during the luteal stage influences the growing follicles’ development. Methods: A randomized controlled trial was performed. 114 infertile couples undergoing intracytoplasmic sperm injection—embryo transfer were included and divided equally into two groups. Group 1: 57 women received estradiol (E2) pretreatment and then underwent an ICSI cycle, Group 2: 57 women who directly underwent ICSI without pretreatment. The ovarian response was evaluated, and A fixed antagonist protocol was employed in both groups. Day 3 ET of good quality embryos were applied. Results: Group 2 was significantly higher on stimulation days, daily dose of hMG, and gonadotropin ampoules than in Group 1. Number of follicles on day of hCG in group 1 was 9.81± 5.42 and in group 2 was 10.60± 6.54 (P=0.803), also no difference was observed in the number of mature oocytes or the number of high-quality embryos between the two groups. The clinical pregnancy rate was insignificantly increased, in patients received E2, 66.7% vs. 54.4%, in group 1 and group 2, respectively (P = 0.180). The implantation rate increased significantly in group 1 than in group 2 (49.70±41.99% vs. 35.93±39.85%, respectively; P = 0.045). Conclusion: Estradiol pretreatment in antagonist cycles improves the positive pregnancy rate and implantation rate with a tendency to require lower hMG doses and a shorter stimulation duration. | ||
| Keywords | ||
| Follicular synchronization; Estradiol pretreatment; antagonist protocol; ICSI | ||
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