The Effect of L-Arginine onDiabetic Male Sex Organs | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 2, Volume 27, Issue 1, June 2007, Pages 15-28 PDF (149.13 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2007.37108 | ||
| Authors | ||
| Mahmoud EL-Gharieb* 1; Thanaa EL– Masry2 | ||
| 1Department of Physiology, Faculty of Medicine | ||
| 2Department of Pharmacology Facultyof Pharmacy, Tanta University | ||
| Abstract | ||
| L-arginine is the substrate for the enzyme nitric oxide synthase ( NOS ), which is responsible for the production of nitric oxide (NO), an endogenous messenger molecule involved in many metabolic processes. The purpose of this work was to evaluate the effect of L -arginine on male sex organs under diabetic conditions. In this study three groups of adult male rats were used, the first as control, the second was alloxan – induced diabetic rats under control by insulin and the third was like the second but was treated with L-arginine for four weeks. At the end of the experiment , the rats were killed . The serum level of glucose, testosterone, body weight, serum cholesterol, penile nitric oxide synthase (NOS) activity, arginase activity in (seminal vesicle and prostate gland), lag time and erection time were estimated. The glucose level was significantly increased in both second and third groups due to effect of alloxan and was less significantly increased inthe third group due to the effect of L– arginine. There was also significant decreasein serum testosterone in the second and the third groups in relation to the control group, with no significant change between the second and third groups. There was a significant increase in the level of serum cholesterol and in the lag time in both groups 2 and 3, with significant decrease in the third group in relation to the second group. The other remaining parameters showed a significant decrease in both second and third groups in relation to the control group with significant improvement in the third group when compared with the second group due to the effect of giving L-arginine . We suggest that these findings due to the beneficial effect of L- arginine on the sexual functions of the male sex organs that were affected by diabetes. | ||
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