Clinicopathological Characteristics of Breast Cancer: A local Institutional Experience | ||
| SECI Oncology Journal | ||
| Volume 12, Issue 3, July 2024, Pages 220-227 | ||
| Abstract | ||
| Background and aim of the work: Breast cancer (BC) is the most prevalent type of cancer among Egyptian women. This study was undertaken to evaluate the clinic-pathological profile of BC patients at South Egypt Cancer Institution (SECI), a tertiary-care cancer center at Upper Egypt. Methods: This one year prospective study included all BC patients registered at our institution from the first of February 2022 up to the end of January 2023. All studied participants were subjected to detailed data collection about demographic, clinical, pathological characteristics, and treatment details. Results: We included 75 adult females with newly diagnosed non-metastatic BC, with a mean age of 47.05±11.94 years (range; 25- 74 years). The majority of the studied cases (76%) underwent modified radical mastectomy (MRM). Infiltrating ductal carcinoma (92.0%) was the most common histopathological subtype. 69.3% and 30.7% had tumor grade 2 and 3 respectively. Patients had relatively large tumors at presentation (> 2 cm in 84% of patients). Positive nodal metastasis was documented in 82.7% patients. As regard to biological sub types; luminal A, luminal B (HER2-positive), luminal B (HER2-negative), HER2 amplified and triple negative breast cancer was found in 33.3%, 25.3%, 16%, 12% and 13.3% respectively. 52.0% positive for lymphovascular invasion, and 62.7% positive for perineural invasion. The TNM (AJCC-7th edition) stage distribution was stage I (4.0%), stage II (49.3%), and stage III, (46.7%). During the study period 11 cases (14.7%) show disease progression and one case (1.3%) died. Conclusion: This is a comprehensive data from a single tertiary-care cancer center in Egypt. Thus, dominance of young age and positive nodal metastasis at diagnosis represented the two main features of BC among studied Egyptian women. There is a great need for ongoing public health education programs to enhance awareness about cancer and encourage for national BC screening program. | ||
| Keywords | ||
| Breast cancer; metastasis; clinic-pathological characteristics | ||
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