AMER, A., SAFFAF, A., HAMAWIA, A. (1994). PHARMACOKINETIC PROFILE AND TISSUE DISTRIBUTION OF APRAMYCIN IN CHICKENS. test, 42(3), 93-97. doi: 10.21608/vmjg.1994.371644
AZIZA AMER; A SAFFAF; A HAMAWIA. "PHARMACOKINETIC PROFILE AND TISSUE DISTRIBUTION OF APRAMYCIN IN CHICKENS". test, 42, 3, 1994, 93-97. doi: 10.21608/vmjg.1994.371644
AMER, A., SAFFAF, A., HAMAWIA, A. (1994). 'PHARMACOKINETIC PROFILE AND TISSUE DISTRIBUTION OF APRAMYCIN IN CHICKENS', test, 42(3), pp. 93-97. doi: 10.21608/vmjg.1994.371644
AMER, A., SAFFAF, A., HAMAWIA, A. PHARMACOKINETIC PROFILE AND TISSUE DISTRIBUTION OF APRAMYCIN IN CHICKENS. test, 1994; 42(3): 93-97. doi: 10.21608/vmjg.1994.371644

PHARMACOKINETIC PROFILE AND TISSUE DISTRIBUTION OF APRAMYCIN IN CHICKENS

Veterinary Medical Journal (Giza)
Volume 42, Issue 3, July 1994, Pages 93-97    PDF (1.42 M)
Document Type: Original Article
DOI: 10.21608/vmjg.1994.371644
Authors
AZIZA AMER* 1; A SAFFAF2; A HAMAWIA2
1Dept. of Pharmacology, Fac. Vet. Med., Cairo University
2Dept. of Pharmacology, Fac. Vet. Med., Homa Syria.
Abstract
Apramycin (20 mg/kg b. wt.) was administered by intravenous, oral and intramuscular routes in healthy chickens. Following intravenous injection, the blood concentration curve was exponential. The kinetic parameters showed an elimination half-life of 5.97 +0.07 hours' apparent volume of distribution 13.3320.25 L. / kg. and clearance rate of 1.55+0.04 ml/kg/min. Following oral and intramuscular administration of apramycin reached its maximum concentration 4.4620.07 and 5.67+0.14 ug/ml at maximum time. 41.7722.89 and 42.81+5.89 minutes, with interval between doses 5.12+0.04 and 13.55+0.40 respectively. Apramycin was distributed in all tissues with withdrawal time of 3 days following oral and intramuscular administration for 5 days.
Statistics
Article View: 39
PDF Download: 26