FAYED, E., MOHAMED, M., ABDEL AZEEZ, A. (1994). EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS. test, 42(2), 9-14. doi: 10.21608/vmjg.1994.371664
EL-ASHMAWY FAYED; M MOHAMED; A ABDEL AZEEZ. "EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS". test, 42, 2, 1994, 9-14. doi: 10.21608/vmjg.1994.371664
FAYED, E., MOHAMED, M., ABDEL AZEEZ, A. (1994). 'EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS', test, 42(2), pp. 9-14. doi: 10.21608/vmjg.1994.371664
FAYED, E., MOHAMED, M., ABDEL AZEEZ, A. EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS. test, 1994; 42(2): 9-14. doi: 10.21608/vmjg.1994.371664

EFFECT OF THE ANTIBIOTIC, NORFLOXACIN ON BILE FLOW IN GUINEA PIGS

Veterinary Medical Journal (Giza)
Volume 42, Issue 2, April 1994, Pages 9-14    PDF (1.88 M)
Document Type: Original Article
DOI: 10.21608/vmjg.1994.371664
Authors
EL-ASHMAWY FAYED* 1; M MOHAMED1; A ABDEL AZEEZ2
1Dept. pharmacology and physiology, Fac. Veterinary Medicine, Alexandria University, Egypt
2Dept. physiology, Fac. Vet. med. Kafr El-Sheikh, Tanta Univ.
Abstract
In the present study, the effect of the antibiotic, norfloxacin on the bile flow was investigated in anaesthetized guinea pigs. Intramuscular administration of the drug in a dose of 5 mg/kg body weight resulted in a 28% decrease in the bile flow. The cholestatic effect of norfloxacin was not counteracted by administration of the choleric drug, clanobutin sodium. Meanwhile administration of caffeine citrate significantly counteracted the cholestatic effect of norfloxacin. Moreover, norfloxacin has an inhibitoryeffect on the motility of isolated rabbit duodenum and induced relaxation of the isolated guinea pig ilium.
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