Biochemical Study on Some Important Markers in Human Milk | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 22, Volume 27, Issue 1, June 2007, Pages 345-362 PDF (194.33 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2007.37173 | ||
| Authors | ||
| Ramadan Sayed* 1; Tahia Seleem1; Thoria Eldeeb1; Moustafa Abdella2; Aida Mahmoud3 | ||
| 1Department of Biochemistry, Faculty of medicine, Assiut University | ||
| 2Department of Obstetrics and Gynecology, Faculty of Medicine, Sohag University | ||
| 3Department of Biochemistry, Faculty of Medicine, Sohag university | ||
| Abstract | ||
| Human milk offers the infants nutrients with high bioavailability as well as a large number of bioactive components such as lactoferrin, lysozyme and xanthine oxidase enzyme that confer immune and non immune protection against pathogens in the infant's environment. The objective of the present study was to evaluate the changes that occur in the levels of lactoferrin, lysozyme and xanthine oxidase enzyme in the different stages of human milk and to perform correlation between the levels of these protective factors in each stage of human milk and between the level of each and both the age and parity of the mothers. The present study included 80 women divided into 3 groups, Group I: 25 mothers provided colostrum, Group II: 25 mothers provided transitional milk and Group III: 30 mothers provided mature milk. The levels of lactoferrin and lysozyme and the activity of xanthine oxidase enzyme were measured. Lactoferrin level and xanthine oxidase enzyme activity were significantly lower in transitional milk and mature milk than in colostrum (P < 0.0001) and lower in mature milk than in transitional milk (P < 0.01 and P < 0.001) respectively. On the other hand, the level of lysozyme was significantly lower in transitional milk than in colostrum (P < 0.01) but there is no significant difference between mature milk and either transitional milk or colostrum. There is no correlation between the levels of these parameters and either the age or the parity of the mothers in the different stages of human milk. There is significant positive correlation between lysozyme and lactoferrin in group I (r = 0.52, P < 0.01) and xanthine oxidase in group III (r = 0.44, P < 0.05). On the other hand, there was significant negative correlation between lysozyme and lactoferrin in group II (r = 0.55, P < 0.01). In conclusion, human's milk and colostrum contains important bioactive and protective agents that improve the infant's health. | ||
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