Growth Hormone Receptor Expression In HCV-Related Hepatocellular Carcinoma | ||
| Minia Journal of Medical Research | ||
| Articles in Press, Accepted Manuscript, Available Online from 05 August 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjmr.2024.304862.1757 | ||
| Authors | ||
| Mona Abd El-Rahman Abu El-Makarem1; Ahmed Ali Mohamed2; Mahmoud Ragab Mohamed3; Mariana Fathy Kamel4; Mahmoud Gamal Ameen5; Shaimaa F. Kamel6; Alaa El-Deen mostafa Mohammed* 7 | ||
| 1Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt, | ||
| 2Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt. | ||
| 3Internal Medicine , Faculty of Medicine, Minia University | ||
| 4Pathology department, FAculty of MedicineMinia university, Minia, Egypt | ||
| 5Department of Pathology, South Egypt Cancer Institute, Assuit University, Assuit, Egypt | ||
| 6Internal medicine department, Faculty of Medicine, Minia University, Minia, Egypt. | ||
| 7Internal medicine ,Faculty off medicine, Minia University | ||
| Abstract | ||
| ABSTRACT: Background: Hepatocellular carcinoma (HCC) is unquestionably a major obstacle in the way of health progress in Egypt, considering its high incidence and extreme fatality. In Egypt most of HCC cases occur on top of advanced liver cirrhosis where it was believed to represent a growth hormone (GH) resistance state. Meanwhile, one of the major molecular pathways in many solid tumors is that of the GH and its downstream pathways. Aim of the study: To assess the state of expression of growth hormone receptor (GHR) in cases of HCC as compared to those with liver cirrhosis and healthy controls Subjects & Methods: sixty patients were enrolled in this study. They were arranged into three equal groups: the first contained 20 HCC patients, while the second consisted of 20 cirrhotic patients, and the third represented 20 healthy controls. We compared the immunohistochemistry results of liver tissue biopsies for GHR expression to patients' demographic data, clinical and laboratory findings, as well as the tumor's clinicopathological characteristics. Results: It was found that HCC patients levels of GHR expression were lower than cirrhotic and control groups which were also correlated with features of tumor aggressiveness. Conclusion: The down-regulation of GHR was associated with the development and aggressiveness of Hepatitis C-related HCC, regardless of the functional condition of the liver. | ||
| Keywords | ||
| Hepatocellular carcinoma; Growth hormone receptor; Immunohistochemistry | ||
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