AMER, A., OMRAN, R., MOUSA, S. (1994). EFFECT OF PROLNGED ADMINISTRATION OF LARVIN ON ALBINO RATS. test, 42(1), 271-276. doi: 10.21608/vmjg.1994.372087
AZIZA AMER; REWHIA OMRAN; S MOUSA. "EFFECT OF PROLNGED ADMINISTRATION OF LARVIN ON ALBINO RATS". test, 42, 1, 1994, 271-276. doi: 10.21608/vmjg.1994.372087
AMER, A., OMRAN, R., MOUSA, S. (1994). 'EFFECT OF PROLNGED ADMINISTRATION OF LARVIN ON ALBINO RATS', test, 42(1), pp. 271-276. doi: 10.21608/vmjg.1994.372087
AMER, A., OMRAN, R., MOUSA, S. EFFECT OF PROLNGED ADMINISTRATION OF LARVIN ON ALBINO RATS. test, 1994; 42(1): 271-276. doi: 10.21608/vmjg.1994.372087

EFFECT OF PROLNGED ADMINISTRATION OF LARVIN ON ALBINO RATS

Veterinary Medical Journal (Giza)
Volume 42, Issue 1, January 1994, Pages 271-276    PDF (1.85 M)
Document Type: Original Article
DOI: 10.21608/vmjg.1994.372087
Authors
AZIZA AMER* 1; REWHIA OMRAN2; S MOUSA3
1Dept. Pharmacology., Fac. Vet. Med., Cairo University.
2Animal Health Institute., Poultry Dept., Dokki, Giza.
3Dept. Biochemistry, Fac. Vet. Med., Cairo University.
Abstract
Prolonged oral administration (90 days) of larvin 50 DF to albino rats in doses 1/20 and 1/10 LD50 (19.91) and 39.80mg/kg b. wt.) resulted in a significant increase in Alanine aminotransferase (ALT). Aspartate aminotransferase (AST) and alanine phosphatase activities. Urea and creatinine concentrations were also significantly increased in treated rats as compared with those of control. Total lipids and cholesterol were Significantly decreased. Histopathological examination showed degenerative changes and necrosis in liver, kidney, cardiac muscles, cerebrum and cerebellum. No hematological changes were observed.
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