Does Treadmill Exercise Affect Endothelial Functions In Type 2 Diabetic Patients? | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 1, Volume 27, Issue 2, December 2007, Pages 1-14 PDF (114.69 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2007.37273 | ||
| Authors | ||
| Azza Ismail* 1; Alsayed shanb1; Soheir Abu El Fadl2; Laila Rashed3 | ||
| 1Physical Therapy for Cardiopulmonary Disorders and Geriatrics Department, Faculty of Physical Therapy, Cairo University | ||
| 2Internal Medicine Department, Faculty of Medicine, Cairo University | ||
| 3Biochemistry Department, Faculty of Medicine, Cairo University | ||
| Abstract | ||
| Purpose: The aim of this study was to determine the effect of treadmill exercise training program on nitric oxide (one of endothelial function) in patients with type 2 diabetes mellitus. Subjects and Methods: Thirty type 2 non-smoker diabetic patients selected from the outpatient diabetes clinic of Kasr El Aini hospital. Another thirty age and sex matched non-diabetic healthy control subjects were included in this study. The patients were medically controlled. They were not participating in any form of physical activity and any dietary changes throughout the study. Nitric oxide was measured for the patients and the control subjects at the beginning and at the end of the study. The diabetic patients were divided into two equal groups: Group-I: Fifteen patients practiced moderate treadmill exercise for 40 minutes per session three times weekly for 8 weeks in addition to the oral hypoglycemic drugs. Group-II: Fifteen patients received only the oral hypoglycemic drugs. Results: There was significant reduction in nitric oxide level in diabetic patients (15.59+1.52) than control subjects (23.3+1.99) (P = 0.000). The nitric oxide levels were negatively correlated to the blood glucose levels (fasting & PPBG) in diabeticpatients (r= –0.57 & -0.49; P = 0.008 & 0.01 respectively). Nitric oxide significantly increased after treadmill exercise ingroup-I (22.08 +1.8), (P = 0.000)and its mean value approach that of the control (P= 0.052). There was non- significant change in nitric oxide levels in group-II at the end of the study (15.35 +1.68) (P = 0.797). Conclusion: Treadmill exercise training program with moderateintensity in addition to the oral hypoglycemic drugs increase production ofnitric oxide (improves endothelial function) in type 2 diabetic patients so it was recommended to be applied for those patients. | ||
| Keywords | ||
| Diabetic patient type 2; endothelial function; Nitric oxide; Treadmill exercise | ||
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