The effect of exercise on the levels of circulating leptin in hyperlipidemic patients | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 4, Volume 27, Issue 2, December 2007, Pages 47-62 PDF (218.73 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2007.37289 | ||
| Authors | ||
| Ibraheem El-Akkary* 1; Mohamed El-Ghazali1; Awatef El-Sharkawi2; Bothina Mohamed2; Usama El-Bassiuni2 | ||
| 1Clinical Physiology Departement, Medical Research institute, Alexandria University, Egypt | ||
| 2Applied Medical Biochemistry Departement, Medical Research institute, Alexandria University, Egypt | ||
| Abstract | ||
| This study examined the acute (single bout of exercise) and chronic (exercise training) effects of exercise on plasma lipidlevels in relation to concomittant changes in plasma leptin concentrations. Fourty sedentary adult subjects were categorized into 4 groups, ten in each :lean normolipidemic control, obese normolipidemic, lean hyperlipidemic and obese hyperlipidemic groups. Leptin levels were measured by ELISA method while plasma lipids including total cholestrol (TC), triglycerides (TG), high density lipoprotein-cholestrol (HDL-C), low density lipoprotein-cholestrol (LDL-C), and very low density lipoprotein-cho;estrol (VLDL-C) were measured by conventional colorimetric methods. These measurements were performed before and after acute and chronic exercise. Exercisetraining was a high intensity aerobic exercise performed on cycle ergometer at the level of 85% of maximal predicted heart rate, twice weekly for 12 weeks. Plasma leptin concentrations were significantly higher in normolipidemic (P<0.001) and hyperlipidemic (P <0.01) obese groups and hyperlipidemic (P<0.01) non obese group compared to controls. However, there were no significant correlations between basal serum leptin levels and any of basal serum lipid profile parameters in all studied groups. No significant changes in lipid parameters or leptin concentrations after single bout of exercise. In turn, exercise training induced significant favorable reduction in TC, TG, LDL-C and VLDL-C and increase of HDL-C in all group similar significant reduction in serum leptin levels among the studied groups (P<0.0001). However, there were no significant correlations between the response of leptin to exercise training (expressed as percent reduction from the baseline ) with the associated responses to exercise in any of the lipid profile parameters in all groups. In conclusion, high intensity aerobic exercise training could improve lipid parameters associated with reduction of serum leptin concentration. However, this exercise-induced leptin reduction may restore leptin sensitivity that might regulate metabolic adaptation to exercise. | ||
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