Role of Positron Emission Tomography in Detecting Primary Tumor in Cases of Metastases of Unknown Origin. | ||
| SECI Oncology Journal | ||
| Volume 12, Issue 3, July 2024, Pages 243-248 | ||
| Abstract | ||
| Background: Metastases of unknown origin (MUO) have diverse clinical presentations and, unfortunately, poor outcomes in most cases. Identifying the initial tumor location is still a considerable issue in many MUO cases. Our aim in this research was to assess the ability of F18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) to detect the site of the primary tumor before starting active treatment. Materials and methods: The study included 60 patients referred to our unit as cases of metastatic lesions with unknown primary (34 male, 26 female). PET/CT was done for all patients with its standard protocol. Results: PET/CT could suggest primary lesion in 44 cases (73.3%) with an estimated sensitivity of 97%, specificity 57%, positive predictive value 80.9%, and negative predictive value 91%. Conclusion: PET/CT is a very valuable tool in cases of MUO and is recommended as a diagnostic test for identification of the primary in cancer patients whose primary is unknown. | ||
| Keywords | ||
| Metastasis of unknown origin; Positron emission tomography; Primary tumor detection | ||
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