Marine Endophytic Fungi and the Production of Bioactive Compounds with Antimicrobial Properties | ||
| Journal of Basic and Environmental Sciences | ||
| Volume 11, Issue 1, January 2024, Pages 10-18 PDF (709.17 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbes.2024.373475 | ||
| Authors | ||
| Mohamed H. Yassin1; Ahmed A. Hamed2; Mervat G. Hassan1; Mohamed E. Elawady3; Dina.M.M. Elnagar1 | ||
| 1Microbiology Department, Faculty of Science, Benha University, Benha, Egypt. | ||
| 2Microbial Chemistry Department, National Research Centre, El-Buhouth Street, Dokki, Cairo, Egypt. | ||
| 3Microbial Biotechnology Department, National Research Centre, El- Buhouth Street, Dokki, Cairo, Egypt. | ||
| Abstract | ||
| Marine sponges, renowned for their exceptional biodiversity, serve as natural reservoirs for a wide array of microorganisms, particularly endophytic fungi, which have demonstrated a propensity for synthesizing bioactive compounds with remarkable potential in the realms of antimicrobial and anticancer therapeutics. In the current investigation, marine sponges were meticulously procured from two distinct locales in the coastal waters of Hurghada, Egypt, and their internal tissues were harnessed as a source of endophytic fungi. Isolation techniques were employed to extract and cultivate these endophytic fungi from the sponge tissues. Subsequently, the isolated fungal strains underwent a rigorous screening process to assess their proficiency in generating bioactive compounds possessing potent antimicrobial properties. The evaluation encompassed the efficacy of these compounds against a panel of four pathogenic microorganisms: Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger. This study represents a critical exploration of the endophytic fungal communities dwelling within marine sponges, shedding light on their potential to yield novel bioactive molecules capable of combatting a diverse spectrum of pathogenic microorganisms. The findings offer promising insights into the untapped reservoir of natural products from marine environments, further underscoring their significance in the ongoing pursuit of innovative antimicrobial agents. | ||
| Keywords | ||
| Marine sponges fungi; isolation; Extraction; antimicrobial activity | ||
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