A SHORT REVIEW ON CRYPTOSPORIDIUM AND COLONIC CANCER | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 5, Volume 54, Issue 2, August 2024, Pages 205-212 PDF (4.61 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2024.373519 | ||
| Author | ||
| FATMA H. SHALAAN | ||
| Department of Medical Parasitology, Faculty of Medicine, Menoufia University. Menoufia Governorate, Egypt | ||
| Abstract | ||
| Cryptosporidium is one of the major causes of parasitic diarrhea all over the world. Both animals and humans are impacted. The fecal-oral pathway encompasses the consumption of infected water or food, as well as the intake of oocysts following direct touch with infected humans or animals. There is a lack of treatment alternatives for cryptosporidiosis sufferers. Nitazoxanide is the only one that has been approved by the Food and Drug Administration (FDA) as a therapy for cryptosporidiosis. Colorectal cancers were linked to Cryptosporidium infections. Some diseases, including hematological malignancies and liver cancer were also be linked to infections with Cryptosporidium spp. Infection with Cryptosporidium leads to hyperproliferation, invasion, and resistance to apoptosis and immune responses, via influencing host cellular pathways. While the exact processes that lead to Cryptosporidium-induced intestinal neoplasia remain a mystery, it is evident that they are complex and involve both the parasite and the host. Cancer is the leading cause of death and disability is colon cancer. | ||
| Keywords | ||
| Cryptosporidium; Colon cancer; food contamination; water contamination | ||
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