EFFECTIVENESS OF SELENIUM NANOPARTICLES IN TREATMENT OF SCHISTOSOMA MANSONI INFECTED MICE | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 11, Volume 54, Issue 2, August 2024, Pages 259-266 PDF (1.17 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2024.373526 | ||
| Authors | ||
| Maha M Alabbassy; OLA A. ISMAIL; ISRAA A. ELSKEIKH | ||
| Department of Medical Parasitology, Faculty of Medicine, Suez Canal University, Ismailia Governorate, 41522, Egypt. | ||
| Abstract | ||
| Selenium is an essential micronutrient plays a pivotal role in several physiological and pathological processes, mainly enzymes group called glutathione peroxidase. These enzymes play an important role in detoxification system and give protection against oxidative stress. This study evaluated Selenium nanoparticles (SeNPs) versus Praziquental (PZQ).in treating Schistosoma mansoni- experimentally infected mice. The study included four groups each of 10 male Swiss albino mice; G1: non-infected (control negative, G2: infected and non- treated mice (control positive), G3: Infected and PZQ treated & G4: Infected and SeNPs treated. Evaluation parameters were hepatic egg count, histopathology of liver and spleen tissues, and measurement of superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels. The result showed that hepatic eggs significantly decreased (34%) in PZQ group and markedly reduced (66%) in SeNPs one. Histopathology of liver mean of number granulomas was 4, and reduced to 1.92 &1.12 in PZQ and SeNPs respectively. The reduction percent in SeNPs group increased (72%) with a highly significant granulomal number reduction and reduction in liver fibrosis. The mean diameter of granulomas in PZQ treated mice was reduced by 19.9%, and SeNPs ones by 36%. There was a significant reduction in megakaryocytes (39.45%) in SeNPs group versus (22%) in PZQ one. Schistosomiasis induced a significant reduction in GSH and SOD levels with increased MDA level compared to control negative. Treatment with PZQ and SeNPs significantly increased GSH and SOD levels, and decreased MDA level mainly in SeNPs group. | ||
| Keywords | ||
| Glutathione; Malondialdehyde; Schistosomiasis; Selenium nanoparticles; Superoxide dismutase | ||
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