VONOPRAZAN VERSUS PROTON PUMP INHIBITORS IN COMBINATION WITH ANTIBIOTICS AS A TRIPLE THERAPY FOR ERADICATION OF CLARITHROMYCIN RESISTANT STRAIN OF HELICOBACTER PYLORI | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 17, Volume 54, Issue 2, August 2024, Pages 313-318 PDF (733.49 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2024.373534 | ||
| Authors | ||
| Mostafa Elfors; AHMED M. NAGUIB | ||
| Department of Internal Medicine, Hepatology and GIT Unit, Faculty of Medicine, Ain Shams University, 11566 Cairo, Egypt | ||
| Abstract | ||
| Generally, the common etiology of gastritis infection with Helicobacter pylori (H. pylori) is increasing. Vonoprazan inhibits the activity of H+/K+ ATPases, with greater effect than PPIs on decreasing gastric acidity. This randomized controlled study was performed on two Egyptian patients groups: G1: 160 patients treated with Vonoprazan, Levofloxacin and Amoxicillin for two weeks, and G2: 160 pat-ients treated with Pantoprazole, Levofloxacin andAmoxicillin for two weeks. Testing fecal H. pylori Ag for all patients was done 8 weeks later after the completion of treatment course. The results showed that 136 of 160(85%) patients were negative for H. pylori Ag in G1 compared to 112/160(70%) patients in G2 with the In intention to treat (ITT) analysis and per-protocol (PP) analysis, for eradication rates was in G1greater than in G2 (P = 0.004, 0.002), respectively. | ||
| Keywords | ||
| Vonoprazan; Proton pump inhibitors; Helicobacter pylori; Pantoprazole; Clarithromycin; levofloxacin; Amoxicillin; fecal H. pylori Ag; Intention to treat; per-protocol; resistant strain | ||
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