Resistin, inflammatory biomarkers and insulin resistance in chronic kidney disease | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 20, Volume 27, Issue 2, December 2007, Pages 293-306 PDF (194.16 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2007.37396 | ||
| Authors | ||
| Nagwa Roshdy* 1; Hatem Darwish2; Mohamed El Basel2; Yaser Abdel Hamid2 | ||
| 1Department of Medical Biochemistry, Faculty of Medicine, Cairo University | ||
| 2Department of Internal Medicine, Faculty of Medicine, Cairo University | ||
| Abstract | ||
| In the present study, the role of decreased renal function on resistin was explored. The possible links with inflammation and the insulin resistance present in patients with chronic kidney disease (CKD) were investigated. Post-transplantation changes in these factors and relations were also examined. The study included 83 subjects; 67 patients suffering from chronic kidney diseases and 16 healthy subjects. Participants were classified into the following groups: Group I:16 chronic kidney disease patients on conservative treatment (9 males and 7 females, mean age 42.75 ± 11.7 years). Group II:26 dialysis patients (13 males and 13 females, mean age 43.8 ± 14.6 years). Group III:25 post kidney transplantation patients (13 males, 12 females, mean age 44.2 ± 8.2 years). Group IV:16 healthy, age and sex matched subjects served as control group (8 males and 8 females, mean age 43.50±9.2 years). Estimated glomerular filtration rate (eGFR) was calculated by Modification of Diet in Renal Disease (MDRD) formula. Insulin resistance was estimated using the homeostasis model assessment for insulin resistance (HOMA-IR) index. Serum levels of resistin, hs CRP and IL6 were estimated by ELISA technique. Results showed that circulating resistin levels were significantlyhigher in patient groups compared to the control group. They decreased significantly post-transplantation, yet still higher than normal subjects. These levels showed significantly negative correlation with eGFR. However, resistin levels correlated significantly positive with inflammatory biomarkers (IL6 and hs CRP) in the studied groups. On the other hand, there was no significant correlation between resistinand insulin resistance in any group.In conclusion:Resistin levels correlate with renal function and inflammation in CKD patients. However, it is not a likely mediatorof insulin resistance in those patients. Renal function is an important factor to take into account in clinical studies relating insulin sensitivity to inflammatory biomarkers in CKD | ||
| Keywords | ||
| Chronic Kidney Disease; Glomerular Filtration Rate; Resistin; Insulin Resistance; Inflammation | ||
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