"immunomodulators from natural products" | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 4, Volume 26, Issue 1, June 2006, Pages 47-60 PDF (216.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37422 | ||
| Authors | ||
| M Hifnawy* 1; O Rashwan1; Z Said2; M Rabeh1 | ||
| 1Faculty of Pharmacy, Cairo University , Cairo, Egypt. | ||
| 2Faculty of Medicine, El-Azhar University, Cairo, Egypt | ||
| Abstract | ||
| Immunostimulant plant extractives as well asits isolates constitute an alternative to conventional chemotherapy and prophylaxis of infections. In the present study eight plants (Ecballium elaterium, Luffa cylindrica, Cucurbita maxima, Agaricus bisporous, Pleurotus ostreatus, Oryza sativa (Rica bran), Tropaeolum majus and Echinacea purpurea) were primarily screened for specific and nonspecific immune responses. T. majus and E. elaterium were the most active, in addition to the well known immunostimulant E. purpurea. Tumor Necrosis factor–alfa (TNF-) and gamma Interferon (INF-) production were used as a measure of immunostimulatory activity. "Cucurbitacin D" and "2-0--D-glucopyransoyl cucurbitacin I" of E.elaterium in addition to "5,3'-dihydroxy-7,4'-dimethoxy flavone" and 5,3'-dihydroxy-7,4' dimethoxy flavone – 5-0– glucoside of T. majus were found to significantly stimulate the production of both TNF-and INF-, while , "Androstan" and "4-acetyl-3,5-bis-(methyl thio)-2-pyrrolin-5-Ol" of T. majus stimulated the production of INF-only. | ||
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