Biotechnological Activities of Holothuria papillifera Mortensen, 1938 Inhabiting the Suez Gulf (Northern Red Sea), Egypt | ||
| Egyptian Journal of Aquatic Biology and Fisheries | ||
| Article 82, Volume 28, Issue 4, July and August 2024, Pages 1327-1344 PDF (1.06 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejabf.2024.374268 | ||
| Author | ||
| Moustafa E. Mohamed et al. | ||
| Abstract | ||
| Marine organisms are vast sources of bioactive components, with holothorians, or sea cucumbers being one of these sources. Therefore, sea cucumber specimens were examined as a promising source of natural substances that can be used as antibacterial, antifungal, anti-inflammatory, antioxidant, antiviral, and antitumor agents. Holothuria papillifera wascollected fromZaafarana, Ras Ghareb, and Altur stations and employed as a biological weapon against some pathogens. H. papillifera extracts showed high activity as antibacterial extracts against Staph. aureus and Enterococcus faecalis (Gram+ve), Escherichia coli, Salmonella typhi, and Klebsiella pneumoniae (Gram-ve). It also exhibited positive antifungal efficacy against Candida albicans and revealed moderate activity against liver cancer cells and a weak activity against breast cancer cells. Alternatively, H. papillifera crude extract has weak antiviral activity against CoxB4 and very weak antiviral efficacy against HAV (hepatitis A virus). Moreover, our results proved that H. papillifera extract had anti-inflammatory effects and exhibited antioxidant power. In conclusion, H. papillifera has broad antimicrobial activity against many pathogens, as well as antioxidant, antitumor, anti-inflammatory, among others. It is recommended to explain and characterize the composition of the bioactive compounds of H. papillifera to be included in the pharmaceutical industry | ||
| Keywords | ||
| Cytotoxicity; Antimicrobial; Anti-inflammatory; Red Sea; Holothuria papillifera | ||
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