A study on the protective effects of green tea catechins on heart exposed to microwave induced oxidative damage of male albino rat | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 5, Volume 26, Issue 1, June 2006, Pages 61-74 PDF (84.86 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37429 | ||
| Authors | ||
| Mahmoud EL-Gharieb* ; Romysaa EL-Sherbeny | ||
| Department of Physiology, Faculty of Medicine Tanta University | ||
| Abstract | ||
| The present work was carriedout to investigate the effects of green tea catechin on oxidative damage in microwave exposed male albino rats. The rats were divided into three equal groups each composed of 7 rats. The first group was the control one. The second group was the microwave exposed for 10 minutes for 6 days. The third group rats were exposed to microwave for 6 days and received catechin in a dose of 7gm/diet during microwave exposure which was extended for 4 weeks after exposure. At the end of the experiment the rats were sacrificed and the hearts were dissected and heart microsomes were prepared. The results of the work showed significant increase by microwave exposure in the levels of cytochrome P450and NADPH reductase activity that were significantly reduced by catechin supplementation. Significant reduction by microwave in superoxide dismutase glutathione peroxidase and catalase were increased significantly by catechin. The levels of superoxide radical, lipid peroxide and carbonyl value were significantly increased by microwave exposure and were improved by catechin supplementation. The lipofuscin content of heart was also increased by microwave exposure and was improved by catechin supplementation. It is concluded that, the mixed function oxidase system were activated by microwave exposure, the formation of superoxide radical, lipid peroxide , oxidized protein and lipofuscin were increased and the antioxidative defense system was weakened in heart tissue, but the oxidative damage was significantly reduced by catechin supplementation. | ||
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