Plasma Na + , K + -AT Pase Activity In Some Cardiovascular Diseases in Elderly | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 7, Volume 26, Issue 1, June 2006, Pages 83-94 PDF (153.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37432 | ||
| Authors | ||
| A Al-Malki* ; Taha Kumosani | ||
| Department of Biochemistry, Faculty of Science, King Abdulaziz University, Saudi Arabia | ||
| Abstract | ||
| Cardiovascular diseases, (CVD), are the major cause of early mortality, accounting for almost 25% of deaths globally. CVD events are the net result of integration of several risk factors namely; aging, obesity, hypercholesterolemia, hypertension, diabetes mellitus, smoking and life style. Saudi Arabia has gone through significant urbanization over the last 40 years with significant improvement in social and economical status. This has led to change in lifestyle, accommodating more of the Western habits with respect to diet and physical activity. These factors have either led or augmented other risk factors of CVD. The aim of this study is to provide a helpful test that could be used for the early diagnosis and prognosis of CVD by advancing age through studying plasma activity of the enzyme Na + , K + -ATPase in different classes of CVD such as valvular heart disease, ischemic heart disease, arrhythmia and heart failure in relation to other biochemical parameters as plasma glucose, urea, creatinine, triglyceride, cholesterol, HDL, LDL, Na, K, Mg, Ca, Cl and P besides the relevant plasma enzymes as CK, LDH, AST, ALT compared to a matched normal control group. A total of 95 blood samples were collected from patients of different CVD, in addition to 20 blood samples from normal controls. The age for both groups ranged between 50 and 85 years of both sexes, (78 females and 37 males). The results point to a statistically significant increase in Na+, K+-ATPase activity in most of CVD patients groups under study. Other biochemical parameters showed almost the well known clinically agreed upon pattern. It could be concluded that Na+, K+-ATPase should be added as a predictor test for the diagnostic and prognosis of cardiovascular diseases. | ||
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