Effects of Grape Seed Oil on Liver of Rats | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 8, Volume 26, Issue 1, June 2006, Pages 95-100 PDF (108.03 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37433 | ||
| Author | ||
| Afnan Amer* | ||
| Department of zoology, Girls College for Arts, Science and Education, Ain Shams University | ||
| Abstract | ||
| OBJECTIVES: To study the effect of oral administration of grape seed oil (GSO) against carbontetrachloride (CCl4)-induced hepatotoxicity in rat Liver damage was induced in male Wistar rats (150-200 g) by administering CCl4 (0.5 ml/kg, i.p.) once per day for 7 days and the extent of damage was studied by assessing biochemical parameters such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in serum and concentrations of glutathione (GSH), superoxide dismutase (SOD), and total protein (TP) in liver. The effect of co-administration of GSO (3.7 g/kg, orally) on the above parameters was further investigated and compared with a vitamin E (100 mg/kg, orally) treated group. RESULTS: Oral administration of GSO (3.7 g/kg, body weight orally) for 7 days resulted in a significant reduction in serum AST, ALT, and ALP levels and significant improvement in glutathione, SOD, and TP, when compared with CCl4 damaged rats. The antioxidant effect of GSO at 3.7 g/kg for 7 days was found to be comparable with vitamin E (100 mg/kg, orally) in CCl4-treated rats. CONCLUSION: The GSO has protected the liver from CCl4 damage. Probable mechanism of action may be due to the protection against oxidative damage produced by CCl4. | ||
| Keywords | ||
| Grape seed oil and liver function | ||
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