Evaluation of Thyroid Hormone Levels in Females with Dysfunctional Uterine Bleeding | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 10, Volume 26, Issue 1, June 2006, Pages 119-128 PDF (203.22 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37438 | ||
| Authors | ||
| Mohamed El-Meligui* 1; Dawlat El-Miligy2; Abdel-Hamid Attia1; Omima Hassan3; Neemat Youssef1; Ahmed El-Demery4 | ||
| 1Obstetric & Gynecology Department ; Faculty of Medicine; Cairo University | ||
| 2Medical Biochemistry Department; Faculty of Medicine; Cairo University | ||
| 3Pathology Department ; Faculty of Medicine; Cairo University | ||
| 4Medical Biochemistry Department October 6 University. | ||
| Abstract | ||
| Abnormal uterine bleeding is one of the most frequent gynecologic problems. About 80% of abnormal uterine bleeding are due to hormonal disorders and are called dysfunctional uterine bleeding (DUB). TSH and thyroid hormones dysfunction in women can influence the ovarian cycles by many ways. They can interfere with follicular stimulating hormone (FSH), luteinizing hormone (LH), peripheral metabolism of different steroid hormones, prolactin as well as the metabolism of sex hormone binding globulins (SHBG). The aim of the present study is to evaluate the functional status of thyroid gland in apparently euthyroid women with abnormal menstruation. Three groups of age matched female subjects were studied. Group I included 20 women with menorrhagia, group II comprised 20 women with oligo, hypo or oligo-hypomenorrhea and group III included 20 women with normal menstruation as a control group. Serum TSH, total and free T3&T4, FSH, LH, prolactin, progesterone total and free testosterone were evaluated to all subjects of the study. The results of the present study showed that there was a significant increase in serum total T3, free T3 and total T4, with a significantdecrease in serum TSH hormone among women of group I compared to both groups II and III. There was a significant elevation in serum FSH, LH and total testosterone hormone levels in groups I and II associated with a decrease in serum estradiol, prolactin and free testosterone, compared to control group. Among group I there was a significant negative correlation between serum total T3 and total testosterone hormones and between total T4 and LH hormones. On the other hand, there was a significant positive correlation between serum TSH and estradiol hormone levels in the same group. For group II there was a significant negative correlation between serum thyroid stimulating hormone (TSH) and LH hormone levels. From these results it could be concluded that impaired thyroid functions plays an intimate role on the hypothalamic-pituitary-ovarian axis reflected as dysfunctional uterine bleeding (DUB).It is highly recommended to add thyroid functions as a routine test in the investigations of all cases of DUB | ||
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