The value of cardiac troponin-i as a biochemical markers of acute coronary syndromes compared with other traditional markers | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 9, Volume 26, Issue 2, December 2006, Pages 133-146 PDF (143.83 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37529 | ||
| Authors | ||
| Basant Abd Elrahman* 1; El Sharkawi F1; Gamal Shaban2; Karam Mahdy3; Elmazar MM4 | ||
| 1Biochemistry Department Faculty of Pharmacy, Helwan University | ||
| 2Biochemistry Department, National Heart Institute in Egypt | ||
| 3Medical Biochemistry Department, National Research Center in Egypt | ||
| 4Medical Biochemistry Department, Faculty of Pharmacy, British University in Egypt | ||
| Abstract | ||
| The aim of the present study was to assess the clinical values of serum total Creatine Kinase (Total-CK), Creatine Kinase-MB isoenzyme (CK-MB) and total Lactate Dehydrogenase (LDH) compared with cardiac Troponin-I (cTnI) in the diagnosis of acute coronary syndromes (ACS). The study was carried on 27 patients with acute coronary syndromes from the intensive care unit (ICU) of the Egyptian National Heart Institute (NHI), Imbaba, Giza, Egypt, in addition to 9 healthy age matched subjects served as controls. Patients were classified into 3 groups: Unstable angina group, acute myocardial infarction group with ST-segment elevation and myocardial infarction group with non ST-segment elevation. Blood samples have been taken from the patients on admission to NHI (ICU) and at 24 and 48 hours after their admission. Serum Total-CK, CK-MB, LDH were determined spectrophotometrically and cTnI was determined using Enzyme Linked Immunosorbent Assay (ELISA). The obtained results revealed that there was a positive significant correlation between cTnI and the other biochemical markers except with LDH on admission to NHI (ICU). Percent sensitivity was also determined. On admission both cTnI and CK-MB showed the highest sensitivity (59 %) while after 24 hours of admission, cTnI showed the highest sensitivity (85 %) and after 48 hours of admission LDH showed the highest sensitivity (77 %). Specificity level 100%. In conclusion, the present study showed that cTnI was the most sensitive biochemical marker than the other traditional biochemical markers (Total-CK, CKMB, and LDH) for establishing the diagnosis of ACS during the first 48 hours after admission to the hospital. It is better, however to use a combination of more than one marker in the diagnosis of Acute Coronary Syndrome. | ||
| Keywords | ||
| cardiovascular diseases; Serum Biochemical Markers | ||
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