Comparative study of alcohol clove extract, TiO2 nanoparticles, and clove extract-TiO2 complex in controlling bacterial growth in burn infections | ||
| Microbes and Infectious Diseases | ||
| Articles in Press, Accepted Manuscript, Available Online from 24 August 2024 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2024.309810.2131 | ||
| Authors | ||
| Linda Khalaf Kenawe* ; Ruaa Salam Abbas; Ali Saad Kadhim | ||
| Branch of Biology, Department of Science, College of Basic Education, Wasit University, Wasit, Iraq | ||
| Abstract | ||
| Background: Individuals with burn injuries (BI) are particularly vulnerable to infections. Microbial infection led to morbidity and mortality. This study explored the frequencies of species of bacteria isolated from burn infection (BI) patients. Also, it evaluates the antimicrobial activity of three agents: alcohol clove extract, TiO2 nanoparticles, and clove extract-TiO2 nanoparticles on the growth of bacteria. Seventy swabs collected from BI patients and started in January–April 2024. We used routine methods and the VITEK® to identify species of microbial and antibiotic sensitivity. Additionally, the dilution microplate assay was used to evaluate the minimum inhibitory concentration (MIC) for all agents. The results of the study revealed that VMRSA had a highly frequent score of 42.9%, followed by MARSA and Pseudomonas aeruginosa at 14.3%. According to microbial activity, the lowest concentration inhibition of alcohol clove extract against growth bacterium was 0.37 mg/ml, as well as a concentration of 0.15 mg/ml for TiO2NPs had been virtue inhibition growth bacteria. Furthermore, the agent of clove extract - TiO2NPs at a concentration of 0.18 mg/ml has a significant microbial activity to inhibit the growth of VMRSA more than a single agent microbial with efficacy reaching 100%. Our findings found that VMRSA is a highly prevalent bacterium and at a 0.09 mg/mL concentration of alcohol clove extract -TiO2NPs have been considered the MIC. Also, we suggested that agent has a potential application in medical felids due to their forceful antimicrobial activity | ||
| Keywords | ||
| Clove extract; TiO2NPs; Staphylococcus aureus; burn injure patients | ||
|
Statistics Article View: 180 |
||
