Assay and biochemical effect of long term high dose and abuse administration of ceftriaxone In experimental animals | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 20, Volume 26, Issue 2, December 2006, Pages 327-336 PDF (86.1 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37587 | ||
| Author | ||
| Mansour Mohamed* | ||
| National Organization for Drug Control and Research NODCAR | ||
| Abstract | ||
| Ceftriaxone is a drug proved to have efficacy on community acquired infection including uncomplicated gonorrhea, acute pyelonephritis and various infections in children. Recent studies have demonstrated that ceftriaxone induces reversible precipitates in the gallbladder. This complication is referred to as "biliary pseudolithiasis", and it has symptoms similar to the liver dysfunction usually occurs in children receiving high doses of ceftriaxone. The patient's jaundice subsides, and the liver function test results usually improve, and return to baseline levels after the end duration of treatment. The present study was designed to describe the effect of high dose and abuse treatment of experimental rats with ceftriaxone (500 and 1000 mg/kg B.W.) every 12 hours for one week on liver function tests.. After 7 days of therapy, (ALT, AST), total, direct, and indirect bilirubin levels were evaluated in the experimental rats and the concentration of the drug was determined by high pressure chromatography. The results of the study showed significant elevation in all measured parameters by the end of one week ceftriaxone therapy. Therefore, it could be concluded that the choice of a more safe and potent antibiotics require selective investigation concerning the group of antibiotic, the dosage and the duration as well as the type of disease(1). | ||
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