Can Atorvastatin Modulate The Impact Of Oxidative Stress On Testicular Tissue In Diabetic Rats? | ||
| Bulletin of Egyptian Society for Physiological Sciences | ||
| Article 21, Volume 26, Issue 2, December 2006, Pages 337-356 PDF (234.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/besps.2006.37590 | ||
| Authors | ||
| Eman Shaat* 1; Gehan Soliman2 | ||
| 1Medical Biochemistry Department, Faculty of Medicine, Alexandria University,Egypt. | ||
| 2Physiology Department, Faculty of Medicine, Alexandria University,Egypt. | ||
| Abstract | ||
| The aim of the present study was to evaluate the effect of atorvastatin on some oxidative markers in testes of streptozotocin(STZ)-induced diabetic rats. This study included thirty adult male albino rats divided equally into control group (I), nontreated diabetic group (II) and atorvastatin-treated diabetic group (III). After eight weeks, all rats were sacrificed. In testes, xanthine oxidase(XO) and NADPH oxidase enzyme activities were determined. In addition, reactive oxygen species(ROS) levels were measured using dichlorofluorescein method. Testicular hemeoxygenase-1(HO- 1), testosterone and coenzyme Q10 (CoQ10) were estimated by ELISA and HPLC techniques respectively. The results of this study showed that in STZ-induced diabetic rats, XO and NADPH oxidase activities as well as ROS and HO-1 levels increased significantly as compared to control values , while CoQ10 decreased significantly. Administration of atorvastatin to diabetic rats could significantly reduce XO and NADPH oxidase activities and ROS levels. In addition, it increased CoQ10 and testosterone testicular levels but without apparent effect on hyperglycemia or HO-1 levels. XO, NADPH oxidase, ROS, HO-1 and glucoce was found to correlate positively to each other. In contrast, CoQ10 was inversely correlated to the previously mentioned parameters. These data support the protective antioxidant effect of atorvastatin. This drug could attenuate the oxidative stress induced in testes of STZ-diabetic rats possibly through decreasing XO and NADPH oxidase activities as well as ROS levels and also through increasing antioxidant CoQ10 levels. However, it could not modulate hyperglycemia or testicular HO-1 levels. | ||
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