Activation of human oocytes after previously intracytoplasmic sperm injection (ICSI) fertilization failure | ||
| African Journal of Biological Sciences | ||
| Volume 20, Issue 2, June 2024, Pages 67-78 PDF (290.57 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ajbs.2024.376024 | ||
| Authors | ||
| Osama Mohamed Badr* 1; Mohamed Shehata2; Eman A. Hassan2; Hoda Gamal Alden1 | ||
| 1Animal Biotechnology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City (USC) | ||
| 2International Islamic Center for Population Studies and Research, Al-Azhar University | ||
| Abstract | ||
| Infertility is a major problem that affects the individual and society. The current investigation aimed to investigate the efficiency of activation with ionomycin or 7% ethanol methods to assist oocyte for improving intracytoplasmic sperm injection (ICSI) outcomes in cases of recurrent failure of ICSI including severe male factor infertility, previous failure of fertilization and implantation. Both methods of assisted oocyte activation (AOA) used in this study recorded highly efficient implications on infertility duration, mature and fertilized oocytes, rates of fertilized, cleavage, blastocyst, embryo grades and pregnancy. It was found that using Ionomycin was preferable more than 7% Ethanol in patients’ treatment with failure fertilization with ICSI. | ||
| Keywords | ||
| ICSI; AOA; Infertility; Fertilization | ||
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