Complete blood count indices as inflammatory markers in diabetic patients with active pulmonary tuberculosis | ||
| Journal of Recent Advances in Medicine | ||
| Volume 5, Issue 2, July 2024, Pages 111-120 PDF (1.58 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jram.2024.287173.1243 | ||
| Authors | ||
| Kholoud MA. Zyada* 1; Amany E. Abdelwahab2; Hoda A. Eid2; Asmaa A. El-madbouly3 | ||
| 1Chest Diseases Department, Faculty of Medicine Damietta University, Damietta, Egypt. | ||
| 2Chest Diseases Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| 3Clinical pathology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt. | ||
| Abstract | ||
| Background: The role of hematological indices in follow-up of pulmonary tuberculosis (PTB) has not been extensively investigated. Objectives: To evaluate the role of hematological indices as inflammatory markers in PTB course in diabetes mellitus (DM) and non-diabetes mellitus (NDM) patients. Methodology: The present prospective cohort study included a total of 90 active pulmonary tuberculosis patients. They were grouped into 30 uncontrolled (DM-TB), 30 controlled (DM-TB), and 30 (NDM-TB) patients. All have active smear-positive PTB. The following parameters were reported before starting anti-TB treatment (baseline), and at 1st, and2nd months after starting treatment; mean corpuscle volume (MCV), red blood cell distribution width (RDW), mean corpuscle hemoglobin (MCH), mean corpuscle hemoglobin concentration (MCHC), mean platelet volume (MPV),platelet distribution width (PDW),neutrophil-lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR) and platelet lymphocyte ratio (PLR). Results: the MCV and RDW were significantly higher in the uncontrolled DM-TB group than in the other two groups, and in the controlled DM-TB group than in the NDM-TB group at baseline,1st and2nd months. The RDW was significantly decreased from baseline till 2nd month in the uncontrolled and controlled DM-TB groups. The MPV was significantly lower in uncontrolled DM-TB group than in the other two groups, and in controlled DM-TB group than in the NDM-TB group at baseline, 1st and 2nd months. PDW was significantly reduced in uncontrolled and controlled DM-TB groups than in the NDM-TB group at 2nd month. In the uncontrolled and controlled DM-TB groups, the MPV and PDW were significantly increased during follow-up. The NLR and PLR were significantly higher in uncontrolled DM-TB group than the other two groups and in controlled DM-TB group than in NDM-TB group at 1st month. MLR was significantly higher in uncontrolled DM-TB group than in the other two groups and in controlled DM-TB group than in NDM-TB group at 1st and 2nd months. In uncontrolled DM-TB and controlled DM-TB groups the NLR, PLR, and MLR were decreased during follow-up. Conclusion: The MCV, RDW, MPV, PDW, NLR, PLR and MLR could have an important role in follow-up of PTB in diabetic patients and in predicting treatment outcome. | ||
| Keywords | ||
| complete blood count indices; tuberculosis; Diabetes Mellitus | ||
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